|Source elevation||1,055 meters (3,461 ft)|
|Mouth elevation||275 meters (902 ft)|
The name derives from nôtinikewin (ᓅᑎᓂᑫᐃᐧᐣ), the Cree word for "battle". The name is shared with the settlement of Notikewin, and is lent to the Notikewin Member, a stratigraphical unit of the Western Canadian Sedimentary Basin.
The Notikewin River originates in the Clear Hills of northern Alberta, north of Worsley, at an elevation of 1,055 meters (3,461 ft). It flows in east and north-east, along the southern slopes of the Halverson Ridge, where it receives the waters from the Square Creek and Alleman Creek. It turns east and receives waters from the Rambling Creek, Lovet Creek and Jim Creek.
It flows through the town of Manning, where it is crossed by the Mackenzie Highway and Railink Mackenzie Northern Railway. The settlement of Notikewin is situated immediately north of Manning. The river continues north-east through the Peace Country, receiving the waters of Stowe Creek, Soldar Creek and Hotchkiss River. It continues north-east between Highway 741 and Highway 692, where the Meikle River and Gravina Creek merge into the river, east of Hawk Hills. The river turns east, enters the Notikewin Provincial Park and finally empties into the Peace River at an elevation of 275 meters (902 ft).