Now That's What I Call Music! 43 was released on August 7, 2012. It is the 43rd edition of the Now! series in the United States. It debuted at number one on the Billboard 200 albums chart with sales of 111,000 copies in its first week of release, becoming the 16th number-one album in the series' franchise.
Allmusic critic Andy Kellman notes that "this volume stresses the enduring dominance of European and European-inspired dance-pop" with "only one song without a dance beat: Luke Bryan's "Drunk on You", the token contemporary country inclusion."