Phorbol-12-myristate-13-acetate-induced protein 1

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Phorbol-12-myristate-13-acetate-induced protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PMAIP1 ; APR; NOXA
External IDs OMIM604959 HomoloGene88883 GeneCards: PMAIP1 Gene
RNA expression pattern
PBB GE PMAIP1 204286 s at tn.png
PBB GE PMAIP1 204285 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5366 n/a
Ensembl ENSG00000141682 n/a
UniProt Q13794 n/a
RefSeq (mRNA) NM_021127 n/a
RefSeq (protein) NP_066950 n/a
Location (UCSC) Chr 18:
57.57 – 57.57 Mb
n/a
PubMed search [1] n/a

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.[1][2][3]

Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.[4] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.

Interactions[edit]

Noxa has been shown to interact with:

See also[edit]

References[edit]

  1. ^ Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K (October 1990). "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line". J Virol 64 (10): 4632–9. PMC 247947. PMID 2398525. 
  2. ^ Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene 22 (30): 4675–8. doi:10.1038/sj.onc.1206655. PMID 12879012. 
  3. ^ "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1". 
  4. ^ Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T et al. (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science 288 (5468): 1053–1058. doi:10.1126/science.288.5468.1053. PMID 10807576. 
  5. ^ a b c Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG et al. (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. 
  6. ^ a b Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T et al. (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science 288 (5468): 1053–8. doi:10.1126/science.288.5468.1053. PMID 10807576. 
  7. ^ Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI et al. (June 2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes Dev. 19 (11): 1294–305. doi:10.1101/gad.1304105. PMC 1142553. PMID 15901672. 

Further reading[edit]

External links[edit]