Phorbol-12-myristate-13-acetate-induced protein 1

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Phorbol-12-myristate-13-acetate-induced protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PMAIP1 ; APR; NOXA
External IDs OMIM604959 HomoloGene88883 GeneCards: PMAIP1 Gene
RNA expression pattern
PBB GE PMAIP1 204286 s at tn.png
PBB GE PMAIP1 204285 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5366 n/a
Ensembl ENSG00000141682 n/a
UniProt Q13794 n/a
RefSeq (mRNA) NM_021127 n/a
RefSeq (protein) NP_066950 n/a
Location (UCSC) Chr 18:
57.57 – 57.57 Mb
PubMed search [1] n/a

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.[1][2][3]

Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.[4] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.


Noxa has been shown to interact with MCL1,[5][6] BCL2-like 1[5][7] and Bcl-2.[5][7]

See also[edit]


  1. ^ Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K (October 1990). "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line". J Virol 64 (10): 4632–9. PMC 247947. PMID 2398525. 
  2. ^ Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene 22 (30): 4675–8. doi:10.1038/sj.onc.1206655. PMID 12879012. 
  3. ^ "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1". 
  4. ^ Oda, E.; Ohki R., Murasawa H., Nemoto J., Shibue T., Yamashita T., Tokino T., Taniguchi T. and Tanaka N. (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science 288 (5468): 1053–1058. doi:10.1126/science.288.5468.1053. PMID 10807576. 
  5. ^ a b c Chen, Lin; Willis Simon N, Wei Andrew, Smith Brian J, Fletcher Jamie I, Hinds Mark G, Colman Peter M, Day Catherine L, Adams Jerry M, Huang David C S (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell (United States) 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. ISSN 1097-2765. PMID 15694340. 
  6. ^ Willis, Simon N; Chen Lin, Dewson Grant, Wei Andrew, Naik Edwina, Fletcher Jamie I, Adams Jerry M, Huang David C S (June 2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes Dev. (United States) 19 (11): 1294–305. doi:10.1101/gad.1304105. ISSN 0890-9369. PMC 1142553. PMID 15901672. 
  7. ^ a b Oda, E; Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science (UNITED STATES) 288 (5468): 1053–8. doi:10.1126/science.288.5468.1053. ISSN 0036-8075. PMID 10807576. 

Further reading[edit]

External links[edit]