The town is the headquarters of Malawi Railways. The railway through Nsanje that connects Blantyre with Beira, Mozambique was severely disrupted by the Mozambique Civil War and remains closed. The main road north connecting the town to the rest of Malawi is being upgraded.
A project is currently underway to dredge part of the Shire River in order to make sea transport to Malawi viable. The Shire merges with the Zambezi River, near Cena, Mozambique, and the Zambezi then flows into the Indian Ocean. As of September, 2010, some of the main concrete work on the jetty was complete but the project has foundered due to a lack of investment.
Nsanje lies only about 150 feet above sea level. During the summer months, daytime highs can exceed 120° Fahrenheit.
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