Nuciferine

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Nuciferine
Nuciferine.png
Names
IUPAC name
(6aR)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Other names
(R)-1,2-Dimethoxyaporphine
Identifiers
475-83-2 YesY
ChEMBL ChEMBL464529 N
ChemSpider 9740 N
Jmol-3D images Image
PubChem 3108374
Properties
C19H21NO2
Molar mass 295.376 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. It induces sedation, hypothermia, ptosis, and (in higher doses) catalepsy; it inhibits spontaneous motor activity, conditioned avoidance response, amphetamine toxicity and stereotypy. Nuciferine may also potentiate morphine analgesia. The median lethal dose in mice is 289 mg/kg. It is structurally related to apomorphine.[1][2]

References[edit]

  1. ^ Bhattacharya SK, Bose R, Ghosh P, Tripathi VJ, Ray AB, Dasgupta B (Sep 1978). "Psychopharmacological studies on (—)-nuciferine and its Hofmann degradation product atherosperminine". Psychopharmacology (Berl.) 59 (1): 29–33. doi:10.1007/BF00428026. PMID 100809. 
  2. ^ Spess, David L. Errors in Alkaloids of Nelumbo and Nymphaea species, 2011, academia.edu

See also[edit]