Basal optic nucleus of Meynert
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| Brain: Basal optic nucleus of Meynert | ||
|---|---|---|
| Latin | nucleus basalis telencephali | |
| Gray's | subject #189 813 | |
| NeuroNames | hier-257 | |
| MeSH | Basal+nucleus+of+Meynert | |
N. Basalis of Meynert (NBM) is a group of nerve cells in the substantia innominata of the basal forebrain that has wide projections to the neocortex and is rich in acetylcholine and choline acetyltransferase.
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[edit] Clinical significance
In Parkinson and Alzheimer diseases the nucleus undergoes degeneration. A decrease in acetylcholine production is seen in Alzheimer's disease, Lewy body dementia and some Parkinson disease patients showing abnormal brain function, leading to a general decrease of mental capacity and learning.
Most pharmacological treatments of dementia focus on compensating for a faltering NBM function through artificially increasing acetylcholine levels.
[edit] Cholinergic neurons/cell bodies
The primary concentration of cholinergic neurons/cell bodies that project to the neocortex are in the basal nucleus of Meynert which is located in the substantia innominata of the anterior perforated substance.
[edit] Eponym
It is named for Theodor Meynert.[1]
[edit] References
[edit] External links
This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained within it may be outdated.
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