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Nullification may refer to:
- Nullification (U.S. Constitution), a legal theory that a U.S. state has the right to nullify, or invalidate, any federal law that a state has deemed unconstitutional
- Nullification Crisis, the 1832 confrontation between the U.S. government and South Carolina over the latter's attempt to nullify a federal law
- Jury nullification, a legal term that refers to a jury's ability to deliver a verdict knowingly in contradiction to written law
- Nullification, a form of body modification involving the voluntary removal of body parts
See also 
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