It is considered one of the finest examples of mosques in Ottoman Baroque style. It was built by architects Mustafa Ağa and a Greek minority architect, Simeon Kalfa on one of the seven hills of Istanbul. It was commissioned from the order of Sultan Mahmut I beginning in 1748 and completed by his brother and successor Sultan Osman III in 1755. The architects adopted Baroque architectural elements, the mosque is also distinctive with the absence of an ablution fountain (Turkish: şadırvan). Nuruosmaniye Mosque is located near the entrance to the Kapalıçarşı (Grand Bazaar), Column of Constantine and the historical Gazi Atik Ali Pasha Mosque.
The prayer hall is covered by a single dome 25 m in diameter, it has two minarets with two balconies. The colonnaded portico has a half circle plan, unique for Ottoman mosques. The height of the dome is 43,50 m from the floor level. In the backgarden there is a Türbe (tomb). The mosque is part of a larger complex (Külliye) consisting of a sebil (fountain), medrese, (Islamic school) consisting of 20 domed rooms and one large classroom (dershane), imaret, and the library, which today is part of the Süleymaniye library and contains personal collections of Mahmud I and Osman III with a total of 7,600 volumes of whom 5052 are manuscripts.