Nutrition and pregnancy

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Pregnant woman eating fruit.

Nutrition and pregnancy refers to the nutrient intake, and dietary planning that is undertaken before, during and after pregnancy.

In a precursory study into the link between nutrition and pregnancy in 1950 women who consumed minimal amounts over the eight-week period had a higher mortality or disorder rate concerning their offspring than women who ate regularly, attributed to the fact that the children born to well-fed mothers had less restriction within the womb.[1]

Not only have physical disorders been linked with poor nutrition before and during pregnancy, but neurological disorders and handicaps are a risk that is run by mothers who are malnourished, a condition which can also lead to the child becoming more susceptible to later degenerative disease(s).[2] 23.8% of babies are estimated to be born with lower than optimal weights at birth due to lack of proper nutrition.[3]

It is very important that expecting mothers should change their personal habits like smoking, alcohol, caffeine, using certain medications and street drugs as soon as they know they are pregnant or even when they are planning to conceive. All these can affect the development of the organs like brain, which happen in early stages of pregnancy. They can cause irreparable damage to the growing foetus.[4]

Nutrition before pregnancy[edit]

Beneficial pre-pregnancy nutrients[edit]

As with most diets, there are chances of over-supplementing, however, as general advice, both state and medical recommendations are that mothers follow instructions listed on particular vitamin packaging as to the correct or recommended daily allowance (RDA). Daily prenatal use of iron substantially improves birth weight, potentially reducing the risk of Low birth weight.[5]

  • Magnesium and zinc supplementation for the binding of hormones at their receptor sites.
  • Folic acid supplementation, or dietary requirement of foods containing it for the regular growth of the follicle.
  • Regular vitamin D supplementation decreases the chances of deficiencies in adolescence. More importantly, it is known to reduce the likelihood of rickets with pelvic malformations which make normal delivery impossible.
  • Regular vitamin B12 supplementation, again is known to reduce the chances of infertility and ill health.
  • Omega-3 fatty acids increase blood flow to reproductive organs and may help regulate reproductive hormones.[6] Consumption is also known to help prevent premature delivery and low birth weight.[7] The best dietary source of omega-3 fatty acids is oily fish. Some other omega-3 fatty acids not found in fish can be found in foods such as flaxseeds, walnuts, pumpkin seeds, and enriched eggs.[6]
  • Iron is needed for the healthy growth of the fetus and placenta, especially during the second and third trimesters. It is also essential before pregnancy for the production of hemoglobin.[8]

Nutrition during pregnancy[edit]

The conception and the subsequent weeks afterwards is the time when it is at its most vulnerable, as it is the time when the organs and systems develop within. The energy used to create these systems comes from the energy and nutrients in the mother's circulation, and around the lining of the womb, such is the reason why correct nutrient intake during pregnancy is so important.

During the early stages of pregnancy, since the placenta is not yet formed, there is no mechanism to protect the embryo from the deficiencies which may be inherent in the mother's circulation. Thus, it is critical that an adequate amount of nutrients and energy is consumed. Additionally, the frequent consumption of nutritious foods helps to prevent nausea, vomiting, and cramps.[9] Supplementing one's diet with foods rich in folic acid, such as oranges and dark green leafy vegetables, helps to prevent neural tube birth defects in the baby, which alludes to pregnancy vegetarianism. Consuming foods rich in iron, such as lean red meat and beans help to prevent anemia and ensure adequate oxygen for the baby.[10] A necessary step for proper diet is to take a daily prenatal vitamins, that ensure their body gets the vitamins and minerals it needs to create a healthy baby. These vitamins contain folic acid, iodine, iron, vitamin A, vitamin D, zinc and calcium.[11]

Potentially harmful determinants during pregnancy[edit]

It is advised for pregnant women to pay special attention to food hygiene during pregnancy in addition to avoiding certain foods in order to reduce the risk of exposure to substances that may be harmful to the developing fetus. This can include food pathogens and toxic food components, alcohol, and dietary supplements such as vitamin A.[7]

Dietary vitamin A is obtained in two forms which contain the preformed vitamin (retinol), that can be found in some animal products such as liver and fish liver oils, and as a vitamin A precursor in the form of carotenes, which can be found in many fruits and vegetables.[7] Intake of retinol, in extreme cases, has been linked to birth defects and abnormalities. However, regular intake of retinol is not seen as dangerous. It is noted that a 100 g serving of liver may contain a large amount of retinol, so it is best that it is not eaten daily during pregnancy, something which is also the same with alcohol intake in binge drinking.

Excessive amounts of alcohol have been proven to cause fetal alcohol syndrome. The World Health Organization recommends that alcohol should be avoided entirely during pregnancy, given the relatively unknown effects of even small amounts of alcohol during pregnancy.[12]

Pregnant women are advised to pay particular attention to food hygiene and to avoid certain foods during pregnancy in order to minimize the risk of food poisoning from potentially harmful pathogens such as listeria, toxoplasmosis, and salmonella. Pregnant women are therefore advised to avoid foods in which high levels of the bacteria have been found, such as in soft cheeses. Listeria are destroyed by heat and therefore pregnant women are advised to reheat ready-prepared meals thoroughly. Pregnant women should also wash their fruit and vegetables very thoroughly in order to minimize risk. Salmonella poisoning is most likely to come from raw eggs or undercooked poultry.[7] Maternal obesity has a significant impact on maternal metabolism and offspring development.[13] Insulin resistance, glucose homeostasis, fat oxidation and amino acid synthesis are all disrupted by maternal obesity and contribute to adverse outcomes.[13] Modification of lifestyle is an effective intervention strategy for improvement of maternal metabolism and the prevention of adverse outcomes.[13]

Recommended nutrients during pregnancy[edit]

Nutrient Recommendation (Extra = Above RDA) Maximum/Total amount
Energy Increase by 200 kcal (840 kJ) per day in last trimester only. RDA
Proteins Extra 6 g per day 51 g per day
Thiamin Increase in line with energy; increase by 0.1 mg per day 0.9 mg per day
Riboflavin Needed for tissue growth; extra 0.3 mg per day 1.4 mg per day
Niacin Regular supplementation/diet of substance. No increase required. RDA
Folate Maintain plasma levels; extra 200 µg per day 200 µg per day
Vitamin C Replenish drained maternal stores; extra 120 mg per day 500 mg per day
Vitamin D Replenish plasma levels of vitamin 10 µg per day. RDA
Calcium Needs no increase RDA
Iron Extra 3 mg per day needed RDA
Magnesium, zinc, and copper Normal supplementation or consumption. RDA
Iodine Extra 100 µg per day. 250 µg per day[14][15][16][17]

Folate[edit]

Folic acid, which is the synthetic form of the vitamin folate, is extremely critical both in pre-and peri-conception.[7] Deficiencies in folic acid may cause neural tube defects; women who had 4 mg of folic acid in their systems due to supplementing 3 months before childbirth significantly reduced the risk of NTD within the fetus. This is now advocated by the UK department of health, recommending 400 µg per day of folic acid.

The development of every human cell is dependent on an adequate supply of folic acid. Folic acid governs the synthesis of the precursors of DNA, which is the nucleic acid that gives each cell life and character. Folic acid deficiency results in defective cellular growth and the effects are most obvious on those tissues which grow most rapidly.[18]

Leafy green vegetables, such as cabbage, avocado, broccoli and greens are all good sources of naturally occurring form of folic acid, folate.

Acute lymphoblastic leukemia[edit]

Along with neural tube development, folate affects DNA synthesis in multiple ways. Folate is involved in the construction of purines and pyrimidines, the building blocks of nucleic acids.[19] Folate is also necessary to make s-adenosylmethionine (SAM), which acts as a methyl donor in the synthesis of DNA.[19] Because of its role in these important mechanisms, fetal DNA would be significantly altered if a maternal folate deficiency is present. One possible outcome is DNA mutation, which could prevent normal gene expression. For example, a tumor-suppressing gene might be turned off, altering normal immune function in preventing cancer growth.[19] Thompson et al.[20] examined the relationship between maternal supplementation of folate and iron during pregnancy and incidences of acute lymphoblastic leukemia (ALL) in their children. Increased rates of ALL were found in children whose mothers did not take iron and folate supplements. Iron alone did not seem to reduce the risk of developing ALL, however iron in combination with folate was shown to have a protective effect in decreasing the risk for ALL. Thompson and his associates (2001), concluded that maternal folate supplementation throughout pregnancy plays an important role in reducing the risk for childhood ALL.[20]

Water[edit]

During pregnancy, one's mass increases by about 12 kg.[21] Most of this added weight (6 to 9 L) is water[21] because the plasma volume increases, 85% of the placenta is water[22] and the fetus itself is 70-90% water. This means that hydration should also be considered an important aspect of nutrition throughout pregnancy. To ensure healthy hydration during pregnancy, the European Food Safety Authority recommends an increase of 300 mL per day compared to the normal intake for non-pregnant women, taking the total adequate water intake (from food and fluids) to 2,300 mL, or approximately 1,850 mL/ day from fluids alone.[23]

Nutrition after pregnancy[edit]

Proper nutrition is important after delivery to help the mother recover, and to provide enough food energy and nutrients for a woman to breastfeed her child. Women having serum ferritin <= 70 µg/L may need iron supplements to prevent iron deficiency anaemia during pregnancy and postpartum.[24][25]

During lactation, water intake needs increase to compensate for the loss of water through milk production. Milk is made of 88% water, and the European Food Safety Authority therefore recommends that breastfeeding women increase their water intake by about 700 mL/day, giving an adequate volume of 2,700 mL/day (from food and drink), or approximately 2,200 mL/day from fluids.[23]

See also[edit]

References[edit]

  1. ^ Rasmussen KM (1992). "The influence of maternal nutrition on lactation". Annual Review of Nutrition 12: 103–17. doi:10.1146/annurev.nu.12.070192.000535. PMID 1503799. 
  2. ^ Barasi EM (2003). Human Nutrition - A Health Perspective. London: Arnold. ISBN 0-340-81025-4. 
  3. ^ "WHO | 10 facts on nutrition". World Health Organization. 2011-03-15. Retrieved 2011-08-07. 
  4. ^ Laura Riley. Stephanie Karpinske, ed. Pregnancy: The Ultimate Week-by-Week Pregnancy Guide. Meredith Books. pp. 21–22. ISBN 0-696-22221-3. 
  5. ^ Haider, BA, Olofin, I, Wang, M, et al. (2013). "Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis". British Medical Journal 21. doi:10.1136/bmj.f3443. 
  6. ^ a b Murkoff, Heidi (May 20, 2010). "Foods that make you fertile". Everyday Health. Retrieved 2010-11-30. [unreliable medical source?]
  7. ^ a b c d e Williamson CS (2006). "Nutrition in pregnancy". British Nutrition Foundation 31: 28–59. 
  8. ^ Resnick, Kelly. "A Guide To Supplements For Pregnant Women". SupplementCritique.com. Kelly Resnick. Retrieved 4 October 2014. 
  9. ^ "Common Pregnancy Concerns". OPregnancy. 3 March 2009. Retrieved 24 March 2012. 
  10. ^ "Pregnancy Diet Plan". Retrieved April 22, 2011. [unreliable medical source?]
  11. ^ Laura Riley (2006-02-02). Stephanie Karpinske, ed. Pregnancy: The Ultimate Week-by-Week Pregnancy Guide. Meredith Books. pp. 21–22. ISBN 0-696-22221-3. 
  12. ^ "Framework for alcohol policy in the WHO European Region". World Health Organisation. 
  13. ^ a b c Nelson SM, Matthews P, Poston L (2010). "Maternal metabolism and obesity: modifiable determinants of pregnancy outcome". Hum. Reprod. Update 16 (3): 255–75. doi:10.1093/humupd/dmp050. PMC 2849703. PMID 19966268. 
  14. ^ Zimmermann MB (2007). "The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review". Thyroid 17 (9): 829–35. doi:10.1089/thy.2007.0108. PMID 17956157. 
  15. ^ Pérez-López FR (2007). "Iodine and thyroid hormones during pregnancy and postpartum". Gynecol. Endocrinol. 23 (7): 414–28. doi:10.1080/09513590701464092. PMID 17701774. 
  16. ^ Glinoer D (2007). "Clinical and biological consequences of iodine deficiency during pregnancy". Endocr Dev. Endocrine Development 10: 62–85. doi:10.1159/000106820. ISBN 3-8055-8296-X. PMID 17684390. 
  17. ^ Milman N, Bergholt T, Eriksen L et al. (2005). "Iron prophylaxis during pregnancy -- how much iron is needed? A randomized dose- response study of 20-80 mg ferrous iron daily in pregnant women". Acta Obstet Gynecol Scand 84 (3): 238–47. doi:10.1111/j.0001-6349.2005.00610.x. PMID 15715531. 
  18. ^ Hibbard BM (August 1964). "The role of folic acid in pregnancy". An International Journal of Obstetrics and Gynaecology 71 (4): 529–42. doi:10.1111/j.1471-0528.1964.tb04317.x. 
  19. ^ a b c Ball, George F. M. (2004). Vitamins: Their Role in the Human Body. London: Blackwell. 
  20. ^ a b Thompson, J.R, Fitz Gerald, P., Willoughby, M.L.N., & Armstrong, B.K. (2001). "Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood". Lancet 358 (9297): 1935–1940. doi:10.1016/S0140-6736(01)06959-8. PMID 11747917. 
  21. ^ a b Institute of Medicine (IOM). Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. Washington, DC: National Academies Press, 2004.
  22. ^ Beall MH, van den Wijngaard JPHM, van Gemert MJC, Ross MG. Amniotic Fluid Water Dynamics. Placenta 2007;28:816-23.
  23. ^ a b EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA); Scientific Opinion on Dietary reference values for water. EFSA Journal 2010; 8:1459-1507. doi:10.2903/j.efsa.2010.1459.
  24. ^ Milman N, Byg KE, Bergholt T, Eriksen L, Hvas AM (2006). "Body iron and individual iron prophylaxis in pregnancy--should the iron dose be adjusted according to serum ferritin?". Ann. Hematol. 85 (9): 567–73. doi:10.1007/s00277-006-0141-1. PMID 16733739. 
  25. ^ Sethi V, Kapil U (2004). "Iodine deficiency and development of brain". Indian J Pediatr 71 (4): 325–9. doi:10.1007/BF02724099. PMID 15107513. 

Further reading[edit]