O6-Benzylguanine

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O6-Benzylguanine
Benzylguanine.svg
Identifiers
CAS number 19916-73-5 YesY
PubChem 4578
ChemSpider 4417
Jmol-3D images Image 1
Properties
Molecular formula C12H11N5O
Molar mass 241.25 g mol−1
Density 1.432 g/mL
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as an inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair and increases the potency of other chemotherapeutic agents that damage DNA, such as temozolomide.[1][2]

O6-BG is also used as a biochemical tool in the study of DNA repair mechanisms.

References[edit]

  1. ^ Quinn, JA; Desjardins, A; Weingart, J; Brem, H; Dolan, ME; Delaney, SM; Vredenburgh, J; Rich, J et al. (2005). "Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma". Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23 (28): 7178–87. doi:10.1200/JCO.2005.06.502. PMID 16192602. 
  2. ^ Quinn, J. A.; Jiang, S. X.; Reardon, D. A.; Desjardins, A.; Vredenburgh, J. J.; Rich, J. N.; Gururangan, S.; Friedman, A. H. et al. (2009). "Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults with Recurrent, Temozolomide-Resistant Malignant Glioma". Journal of Clinical Oncology 27 (8): 1262–7. doi:10.1200/JCO.2008.18.8417. PMC 2667825. PMID 19204199. 

External links[edit]