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2'-5'-oligoadenylate synthetase 1, 40/46kDa
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols OAS1 ; IFI-4; OIAS; OIASI
External IDs OMIM164350 HomoloGene1903 GeneCards: OAS1 Gene
EC number
RNA expression pattern
PBB GE OAS1 205552 s at tn.png
PBB GE OAS1 202869 at tn.png
More reference expression data
Species Human Mouse
Entrez 4938 23960
Ensembl ENSG00000089127 ENSMUSG00000066861
UniProt P00973 P11928
RefSeq (mRNA) NM_001032409 NM_011852
RefSeq (protein) NP_001027581 NP_035982
Location (UCSC) Chr 12:
113.34 – 113.37 Mb
Chr 5:
120.88 – 120.89 Mb
PubMed search [1] [2]

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.[1][2]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in both viral and endogenous RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.[3]


  1. ^ Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, Monk S, Carter S, Ross CJ, Pang J, Twells R, Chamberlain S, Monaco AP, Strachan T, Kucherlapati R (Feb 1998). "A sequence-ready physical map of a region of 12q24.1". Genomics 45 (2): 271–8. doi:10.1006/geno.1997.4888. PMID 9344649. 
  2. ^ Nechiporuk T, Nechiporuk A, Sahba S, Figueroa K, Shibata H, Chen XN, Korenberg JR, de Jong P, Pulst SM (Nov 1997). "A high-resolution PAC and BAC map of the SCA2 region". Genomics 44 (3): 321–9. doi:10.1006/geno.1997.4886. PMID 9325053. 
  3. ^ "Entrez Gene: OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa". 

Further reading[edit]