ODF2

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Outer dense fiber of sperm tails 2
Identifiers
Symbols ODF2 ; CT134; ODF2/1; ODF2/2; ODF84
External IDs OMIM602015 MGI1098824 HomoloGene1907 GeneCards: ODF2 Gene
RNA expression pattern
PBB GE ODF2 210415 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4957 18286
Ensembl ENSG00000136811 ENSMUSG00000026790
UniProt Q5BJF6 A3KGV1
RefSeq (mRNA) NM_001242352 NM_001113213
RefSeq (protein) NP_001229281 NP_001106684
Location (UCSC) Chr 9:
131.22 – 131.26 Mb
Chr 2:
29.89 – 29.93 Mb
PubMed search [1] [2]

Outer dense fiber protein 2, also known as cenexin, is a protein that in humans is encoded by the ODF2 gene.[1][2][3]

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of this gene; however, not all isoforms and variants have been fully described.[3]

References[edit]

  1. ^ Shao X, Tarnasky HA, Schalles U, Oko R, van der Hoorn FA (Apr 1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27". J Biol Chem 272 (10): 6105–13. doi:10.1074/jbc.272.10.6105. PMID 9045620. 
  2. ^ Shao X, Murthy S, Demetrick DJ, van der Hoorn FA (Mar 1999). "Human outer dense fiber gene, ODF2, localizes to chromosome 9q34". Cytogenet Cell Genet 83 (3–4): 221–3. doi:10.1159/000015183. PMID 10072582. 
  3. ^ a b "Entrez Gene: ODF2 outer dense fiber of sperm tails 2". 

Further reading[edit]