From Wikipedia, the free encyclopedia
Jump to: navigation, search
Opioid binding protein/cell adhesion molecule-like
External IDs OMIM600632 MGI97397 HomoloGene55663 GeneCards: OPCML Gene
RNA expression pattern
PBB GE OPCML 206215 at tn.png
More reference expression data
Species Human Mouse
Entrez 4978 330908
Ensembl ENSG00000183715 ENSMUSG00000062257
UniProt Q14982 Q6DFY2
RefSeq (mRNA) NM_001012393 NM_177906
RefSeq (protein) NP_001012393 NP_808574
Location (UCSC) Chr 11:
132.28 – 133.4 Mb
Chr 9:
27.79 – 28.93 Mb
PubMed search [1] [2]

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.[1][2]

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID 8244387. 
  2. ^ a b "Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like". 

Further reading[edit]