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Opsin 1 (cone pigments), long-wave-sensitive
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM300822 MGI1097692 HomoloGene68064 GeneCards: OPN1LW Gene
RNA expression pattern
PBB GE OPN1LW 221327 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5956 14539
Ensembl ENSG00000102076 ENSMUSG00000031394
UniProt P04000 O35599
RefSeq (mRNA) NM_020061 NM_008106
RefSeq (protein) NP_064445 NP_032132
Location (UCSC) Chr HG1497_PATCH:
153.31 – 153.33 Mb
Chr X:
74.13 – 74.15 Mb
PubMed search [1] [2]

Red-sensitive opsin is a protein that in humans is encoded by the OPN1LW gene.[1]

This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin, because its main response is for red color wavelengths. Nevertheless, it has a secondary response in the violet high frequencies[2]

Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.