OR7D4

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Olfactory receptor, family 7, subfamily D, member 4
Identifiers
Symbols OR7D4 ; OR19-7; OR19-B; OR19B; OR7D4P; hg105
External IDs OMIM611538 MGI1313142 HomoloGene81583 GeneCards: OR7D4 Gene
Orthologs
Species Human Mouse
Entrez 125958 258822
Ensembl ENSG00000174667 ENSMUSG00000059623
UniProt Q8NG98 Q7TRF3
RefSeq (mRNA) NM_001005191 NM_146825
RefSeq (protein) NP_001005191 NP_667036
Location (UCSC) Chr 19:
9.32 – 9.33 Mb
Chr 9:
20.28 – 20.29 Mb
PubMed search [1] [2]

Olfactory receptor 7D4 is a protein that in humans is encoded by the OR7D4 gene.[1][2][3][4][5][6][7]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

References[edit]

  1. ^ a b "Entrez Gene: OR7D4 olfactory receptor, family 7, subfamily D, member 4". Retrieved 2013-12-17. 
  2. ^ Fuchs, T.; Malecova, B.; Linhart, C.; Sharan, R.; Khen, M.; Herwig, R.; Shmulevich, D.; Elkon, R.; Steinfath, M.; O'Brien, J. K.; Radelof, U.; Lehrach, H.; Lancet, D.; Shamir, R. (2002). "DEFOG: A Practical Scheme for Deciphering Families of Genes". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.  edit
  3. ^ Malnic, B.; Godfrey, P. A.; Buck, L. B. (2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.  edit
  4. ^ Keller, A.; Zhuang, H.; Chi, Q.; Vosshall, L. B.; Matsunami, H. (2007). "Genetic variation in a human odorant receptor alters odour perception". Nature 449 (7161): 468–472. doi:10.1038/nature06162. PMID 17873857.  edit
  5. ^ OR7D4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
  6. ^ Lunde, K.; Egelandsdal, B. R.; Skuterud, E.; Mainland, J. D.; Lea, T.; Hersleth, M.; Matsunami, H. (2012). Behrens, Maik, ed. "Genetic Variation of an Odorant Receptor OR7D4 and Sensory Perception of Cooked Meat Containing Androstenone". PLoS ONE 7 (5): e35259. doi:10.1371/journal.pone.0035259. PMC 3342276. PMID 22567099.  edit
  7. ^ Wysocki, C. J.; Beauchamp, G. K. (1984). "Ability to smell androstenone is genetically determined". Proceedings of the National Academy of Sciences of the United States of America 81 (15): 4899–4902. doi:10.1073/pnas.81.15.4899. PMC 391599. PMID 6589634.  edit


This article incorporates text from the United States National Library of Medicine, which is in the public domain.