ORC2

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Origin recognition complex, subunit 2
Identifiers
Symbols ORC2 ; ORC2L
External IDs OMIM601182 MGI1328306 HomoloGene4512 GeneCards: ORC2 Gene
RNA expression pattern
PBB GE ORC2L 204853 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4999 18393
Ensembl ENSG00000115942 ENSMUSG00000026037
UniProt Q13416 Q60862
RefSeq (mRNA) NM_006190 NM_001025378
RefSeq (protein) NP_006181 NP_001020549
Location (UCSC) Chr 2:
201.77 – 201.83 Mb
Chr 1:
58.46 – 58.51 Mb
PubMed search [1] [2]
Origin recognition complex subunit 2
Identifiers
Symbol ORC2
Pfam PF04084
InterPro IPR007220

Origin recognition complex subunit 2 is a protein that in humans is encoded by the ORC2 (ORC2L) gene.[1][2]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, ORC4, and ORC5. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.[2]

Interactions[edit]

ORC2 has been shown to interact with ORC1,[3][4][5][6] Replication protein A1,[3] ORC4,[3][5][7][8] ORC5,[3][5][7][9] ORC3,[3][5][7][10][11] MCM4,[3] CDC6,[3][12] MCM5,[3] MCM6,[3] MCM7,[3] MCM10,[13] DBF4,[3] MCM2[3] and ORC6.[3][5]

References[edit]

  1. ^ Takahara K, Bong M, Brevard R, Eddy RL, Haley LL, Sait SJ, Shows TB, Hoffman GG, Greenspan DS (October 1996). "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L". Genomics 31 (1): 119–122. doi:10.1006/geno.1996.0018. PMID 8808289. 
  2. ^ a b "Entrez Gene: ORC2L origin recognition complex, subunit 2-like (yeast)". 
  3. ^ a b c d e f g h i j k l m Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–128. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  4. ^ Fujita, Masatoshi; Ishimi Yukio; Nakamura Hiromu; Kiyono Tohru; Tsurumi Tatsuya (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. (United States) 277 (12): 10354–10361. doi:10.1074/jbc.M111398200. ISSN 0021-9258. PMID 11779870. 
  5. ^ a b c d e Vashee, S; Simancek P; Challberg M D; Kelly T J (July 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. (United States) 276 (28): 26666–26673. doi:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433. 
  6. ^ Méndez, Juan; Zou-Yang X Helena, Kim So-Young, Hidaka Masumi, Tansey William P, Stillman Bruce (March 2002). "Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication". Mol. Cell (United States) 9 (3): 481–491. doi:10.1016/S1097-2765(02)00467-7. ISSN 1097-2765. PMID 11931757. 
  7. ^ a b c Dhar, S K; Delmolino L; Dutta A (August 2001). "Architecture of the human origin recognition complex". J. Biol. Chem. (United States) 276 (31): 29067–29071. doi:10.1074/jbc.M103078200. ISSN 0021-9258. PMID 11395502. 
  8. ^ Quintana, D G; Hou Zh; Thome K C; Hendricks M; Saha P; Dutta A (November 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". J. Biol. Chem. (United States) 272 (45): 28247–28251. doi:10.1074/jbc.272.45.28247. ISSN 0021-9258. PMID 9353276. 
  9. ^ Quintana, D G; Thome K C; Hou Z H; Ligon A H; Morton C C; Dutta A (October 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". J. Biol. Chem. (United States) 273 (42): 27137–27145. doi:10.1074/jbc.273.42.27137. ISSN 0021-9258. PMID 9765232. 
  10. ^ Matsuoka, Shuhei; Ballif Bryan A, Smogorzewska Agata, McDonald E Robert, Hurov Kristen E, Luo Ji, Bakalarski Corey E, Zhao Zhenming, Solimini Nicole, Lerenthal Yaniv, Shiloh Yosef, Gygi Steven P, Elledge Stephen J (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science (United States) 316 (5828): 1160–1166. doi:10.1126/science.1140321. PMID 17525332. 
  11. ^ Pinto, S; Quintana D G, Smith P, Mihalek R M, Hou Z H, Boynton S, Jones C J, Hendricks M, Velinzon K, Wohlschlegel J A, Austin R J, Lane W S, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron (United States) 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. ISSN 0896-6273. PMID 10402192. 
  12. ^ Méndez, J; Stillman B (November 2000). "Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis". Mol. Cell. Biol. (United States) 20 (22): 8602–8612. doi:10.1128/MCB.20.22.8602-8612.2000. ISSN 0270-7306. PMC 102165. PMID 11046155. 
  13. ^ Izumi, M; Yanagi K; Mizuno T; Yokoi M; Kawasaki Y; Moon K Y; Hurwitz J; Yatagai F; Hanaoka F (December 2000). "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase". Nucleic Acids Res. (ENGLAND) 28 (23): 4769–4777. doi:10.1093/nar/28.23.4769. PMC 115166. PMID 11095689. 

Further reading[edit]