Origin recognition complex subunit 2 is a protein that in humans is encoded by the ORC2 (ORC2L) gene.
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, ORC4, and ORC5. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.
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Quintana DG, Hou Zh, Thome KC et al. (1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". J. Biol. Chem.272 (45): 28247–28251. doi:10.1074/jbc.272.45.28247. PMID9353276.
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Pinto S, Quintana DG, Smith P et al. (1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. PMID10402192.
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