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Origin recognition complex (ORC) subunit 3 N-terminus
Symbol ORC3_N
Pfam PF07034
InterPro IPR010748
Origin recognition complex, subunit 3
External IDs OMIM604972 MGI1354944 HomoloGene8225 GeneCards: ORC3 Gene
RNA expression pattern
PBB GE ORC3L 210028 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23595 50793
Ensembl ENSG00000135336 ENSMUSG00000040044
UniProt Q9UBD5 Q9JK30
RefSeq (mRNA) NM_001197259 NM_001159563
RefSeq (protein) NP_001184188 NP_001153035
Location (UCSC) Chr 6:
88.3 – 88.38 Mb
Chr 4:
34.57 – 34.61 Mb
PubMed search [1] [2]

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.[1][2][3]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.[3]


ORC3 has been shown to interact with ORC2,[2][4][5][6][7] MCM7,[4] ORC4,[2][5][7] ORC5,[2][4][5][7] MCM4[4] and ORC6.[4][7]


  1. ^ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Jan 1999). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". J Biol Chem 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972. 
  2. ^ a b c d Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (Jul 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. PMID 10402192. 
  3. ^ a b "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)". 
  4. ^ a b c d e Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  5. ^ a b c Dhar, S K; Delmolino L; Dutta A (Aug 2001). "Architecture of the human origin recognition complex". J. Biol. Chem. (United States) 276 (31): 29067–71. doi:10.1074/jbc.M103078200. ISSN 0021-9258. PMID 11395502. 
  6. ^ Matsuoka, Shuhei; Ballif Bryan A, Smogorzewska Agata, McDonald E Robert, Hurov Kristen E, Luo Ji, Bakalarski Corey E, Zhao Zhenming, Solimini Nicole, Lerenthal Yaniv, Shiloh Yosef, Gygi Steven P, Elledge Stephen J (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science (United States) 316 (5828): 1160–6. doi:10.1126/science.1140321. PMID 17525332. 
  7. ^ a b c d Vashee, S; Simancek P; Challberg M D; Kelly T J (Jul 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. (United States) 276 (28): 26666–73. doi:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433. 

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