Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.
^ abQuintana DG, Hou Zh, Thome KC, Hendricks M, Saha P, Dutta A (December 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". J Biol Chem272 (45): 28247–51. doi:10.1074/jbc.272.45.28247. PMID9353276.
^Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenet Cell Genet81 (1): 89–90. doi:10.1159/000014997. PMID9691185.
^Quintana, D G; Thome K C; Hou Z H; Ligon A H; Morton C C; Dutta A (October 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". J. Biol. Chem. (UNITED STATES) 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. ISSN0021-9258. PMID9765232.
^Pinto, S; Quintana D G, Smith P, Mihalek R M, Hou Z H, Boynton S, Jones C J, Hendricks M, Velinzon K, Wohlschlegel J A, Austin R J, Lane W S, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron (UNITED STATES) 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. ISSN0896-6273. PMID10402192.Cite uses deprecated parameters (help)
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Tugal T, Zou-Yang XH, Gavin K et al. (1999). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". J. Biol. Chem.273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID9829972.
Springer J, Kneissl M, Pütter V, Grummt F (1999). "Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex". Chromosoma108 (4): 243–9. doi:10.1007/s004120050374. PMID10460412.
Thome KC, Dhar SK, Quintana DG et al. (2001). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". J. Biol. Chem.275 (45): 35233–41. doi:10.1074/jbc.M005765200. PMID10954718.
Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol.327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID12614612.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.