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Origin recognition complex, subunit 4
Symbols ORC4 ; ORC4L; ORC4P
External IDs OMIM603056 MGI1347043 HomoloGene8059 GeneCards: ORC4 Gene
RNA expression pattern
PBB GE ORC4L 203351 s at tn.png
PBB GE ORC4L 203352 at tn.png
More reference expression data
Species Human Mouse
Entrez 5000 26428
Ensembl ENSG00000115947 ENSMUSG00000026761
UniProt O43929 O88708
RefSeq (mRNA) NM_001190879 NM_001177313
RefSeq (protein) NP_001177808 NP_001170784
Location (UCSC) Chr 2:
148.69 – 148.78 Mb
Chr 2:
48.9 – 48.95 Mb
PubMed search [1] [2]

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.[1][2][3]

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.[3]


ORC4 has been shown to interact with ORC1,[4] MCM6,[4] ORC2,[1][4][5][6] ORC5,[4][5][7] ORC3,[5][6][8] MCM2,[4] MCM4,[4] MCM3[4] and ORC6.[4]


  1. ^ a b Quintana DG, Hou Zh, Thome KC, Hendricks M, Saha P, Dutta A (December 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". J Biol Chem 272 (45): 28247–51. doi:10.1074/jbc.272.45.28247. PMID 9353276. 
  2. ^ Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenet Cell Genet 81 (1): 89–90. doi:10.1159/000014997. PMID 9691185. 
  3. ^ a b "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)". 
  4. ^ a b c d e f g h Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  5. ^ a b c Dhar, S K; Delmolino L; Dutta A (August 2001). "Architecture of the human origin recognition complex". J. Biol. Chem. (United States) 276 (31): 29067–71. doi:10.1074/jbc.M103078200. ISSN 0021-9258. PMID 11395502. 
  6. ^ a b Vashee, S; Simancek P; Challberg M D; Kelly T J (July 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. (United States) 276 (28): 26666–73. doi:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433. 
  7. ^ Quintana, D G; Thome K C; Hou Z H; Ligon A H; Morton C C; Dutta A (October 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". J. Biol. Chem. (UNITED STATES) 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. ISSN 0021-9258. PMID 9765232. 
  8. ^ Pinto, S; Quintana D G, Smith P, Mihalek R M, Hou Z H, Boynton S, Jones C J, Hendricks M, Velinzon K, Wohlschlegel J A, Austin R J, Lane W S, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron (UNITED STATES) 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. ISSN 0896-6273. PMID 10402192. 

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