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Origin recognition complex, subunit 5
Symbols ORC5 ; ORC5L; ORC5P; ORC5T; PPP1R117
External IDs OMIM602331 MGI1347044 HomoloGene37636 GeneCards: ORC5 Gene
RNA expression pattern
PBB GE ORC5L 204957 at tn.png
PBB GE ORC5L 211212 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5001 26429
Ensembl ENSG00000164815 ENSMUSG00000029012
UniProt O43913 Q9WUV0
RefSeq (mRNA) NM_001197292 NM_011959
RefSeq (protein) NP_002544 NP_036089
Location (UCSC) Chr 7:
103.77 – 103.85 Mb
Chr 5:
22.49 – 22.55 Mb
PubMed search [1] [2]

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.[1][2][3]

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and 4L. Alternatively spliced transcript variants encoding distinct isoforms have been described.[3]


ORC5 has been shown to interact with ORC1,[4] ORC2,[4][5][6][7] MCM7,[4] ORC4,[4][5][6] ORC3,[4][6][7][8] MCM2,[4] MCM4[4] and MCM3.[4]


  1. ^ Ishiai M, Dean FB, Okumura K, Abe M, Moon KY, Amin AA, Kagotani K, Taguchi H, Murakami Y, Hanaoka F, O'Donnell M, Hurwitz J, Eki T (Feb 1998). "Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22". Genomics 46 (2): 294–8. doi:10.1006/geno.1997.5003. PMID 9417919. 
  2. ^ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Jan 1999). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". J Biol Chem 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972. 
  3. ^ a b "Entrez Gene: ORC5L origin recognition complex, subunit 5-like (yeast)". 
  4. ^ a b c d e f g h Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  5. ^ a b Quintana, D G; Thome K C; Hou Z H; Ligon A H; Morton C C; Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". J. Biol. Chem. (United States) 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. ISSN 0021-9258. PMID 9765232. 
  6. ^ a b c Dhar, S K; Delmolino L; Dutta A (Aug 2001). "Architecture of the human origin recognition complex". J. Biol. Chem. (United States) 276 (31): 29067–71. doi:10.1074/jbc.M103078200. ISSN 0021-9258. PMID 11395502. 
  7. ^ a b Vashee, S; Simancek P; Challberg M D; Kelly T J (Jul 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. (United States) 276 (28): 26666–73. doi:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433. 
  8. ^ Pinto, S; Quintana D G, Smith P, Mihalek R M, Hou Z H, Boynton S, Jones C J, Hendricks M, Velinzon K, Wohlschlegel J A, Austin R J, Lane W S, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron (United States) 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. ISSN 0896-6273. PMID 10402192. 

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