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Orosomucoid 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ORM1 ; AGP-A; AGP1; HEL-S-153w; ORM
External IDs OMIM138600 MGI97445 HomoloGene128040 ChEMBL: 4285 GeneCards: ORM1 Gene
RNA expression pattern
PBB GE ORM1 205041 s at tn.png
PBB GE ORM1 205040 at tn.png
PBB GE ORM1 214465 at tn.png
More reference expression data
Species Human Mouse
Entrez 5004 18405
Ensembl ENSG00000229314 ENSMUSG00000039196
UniProt P02763 Q60590
RefSeq (mRNA) NM_000607 NM_008768.1
RefSeq (protein) NP_000598 NP_032794.1
Location (UCSC) Chr 9:
117.09 – 117.09 Mb
Chr 4:
63.01 – 63.01 Mb
PubMed search [1] [2]

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.[1]

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.[1]


ORM1 has been shown to interact with Plasminogen activator inhibitor-1.[2]

See also[edit]


  1. ^ a b "Entrez Gene: ORM1 orosomucoid 1". 
  2. ^ Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity". J. Biol. Chem. (United States) 276 (38): 35305–11. doi:10.1074/jbc.M104028200. ISSN 0021-9258. PMID 11418606. 

Further reading[edit]

  • Treuheit MJ, Costello CE, Halsall HB (1992). "Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.". Biochem. J. 283 (1): 105–12. PMC 1131000. PMID 1567356. 
  • Dente L, Ciliberto G, Cortese R (1985). "Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.". Nucleic Acids Res. 13 (11): 3941–52. doi:10.1093/nar/13.11.3941. PMC 341288. PMID 2409529. 
  • Dubé JY, Paradis G, Têtu B, Tremblay RR (1989). "Synthesis of alpha 1-acid glycoprotein by the human prostate.". Prostate 15 (3): 251–8. doi:10.1002/pros.2990150305. PMID 2479939. 
  • Zuffardi O, Caiulo A, Maraschio P et al. (1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?". Hum. Genet. 82 (1): 17–9. doi:10.1007/bf00288264. PMID 2541064. 
  • Dente L, Pizza MG, Metspalu A, Cortese R (1987). "Structure and expression of the genes coding for human alpha 1-acid glycoprotein.". EMBO J. 6 (8): 2289–96. PMC 553631. PMID 2822385. 
  • Merritt CM, Board PG (1988). "Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene.". Gene 66 (1): 97–106. doi:10.1016/0378-1119(88)90228-4. PMID 2970990. 
  • Dente L, Rüther U, Tripodi M et al. (1988). "Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice.". Genes Dev. 2 (2): 259–66. doi:10.1101/gad.2.2.259. PMID 3360326. 
  • Rocchi M, Roncuzzi L, Santamaria R et al. (1986). "Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9.". Hum. Genet. 74 (1): 30–3. doi:10.1007/BF00278781. PMID 3463531. 
  • Board PG, Jones IM, Bentley AK (1986). "Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.". Gene 44 (1): 127–31. doi:10.1016/0378-1119(86)90051-X. PMID 3770479. 
  • Krauss E, Polnaszek CF, Scheeler DA et al. (1987). "Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera.". J. Pharmacol. Exp. Ther. 239 (3): 754–9. PMID 3795040. 
  • Ikenaka T, Ishiguro M, Emura J et al. (1972). "Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.". Biochemistry 11 (20): 3817–29. doi:10.1021/bi00770a022. PMID 4561179. 
  • Schmid K, Bürgi W, Collins JH, Nanno S (1974). "The disulfide bonds of alpha1-acid glycoprotein.". Biochemistry 13 (13): 2694–7. doi:10.1021/bi00710a006. PMID 4603214. 
  • Schmid K, Kaufmann H, Isemura S et al. (1973). "Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.". Biochemistry 12 (14): 2711–24. doi:10.1021/bi00738a026. PMID 4711474. 
  • Mbuyi JM, Dequeker J, Bloemmen F, Stevens E (1982). "Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE.". Calcif. Tissue Int. 34 (3): 229–31. doi:10.1007/BF02411242. PMID 6809283. 
  • Rabehi L, Ferriere F, Saffar L, Gattegno L (1995). "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans.". Glycoconj. J. 12 (1): 7–16. doi:10.1007/BF00731863. PMID 7795416. 
  • Matoba R, Okubo K, Hori N et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819. 
  • Nakamura T, Board PG, Matsushita K et al. (1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis.". Inflammation 17 (1): 33–45. doi:10.1007/BF00916390. PMID 8432561. 
  • Yuasa I, Umetsu K, Vogt U et al. (1997). "Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.". Hum. Genet. 99 (3): 393–8. doi:10.1007/s004390050378. PMID 9050929. 
  • Morin D, Simon N, Deprés-Brummer P et al. (1997). "Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum.". Pharmacology 54 (5): 271–5. doi:10.1159/000139495. PMID 9380773. 
  • Nakamura H, Yuasa I, Umetsu K et al. (2000). "The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2.". Biochem. Biophys. Res. Commun. 276 (2): 779–84. doi:10.1006/bbrc.2000.3522. PMID 11027547.