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Oxysterol binding protein 2
Symbols OSBP2 ; HLM; ORP-4; ORP4; OSBPL1; OSBPL4
External IDs OMIM606729 MGI1921559 HomoloGene75303 GeneCards: OSBP2 Gene
RNA expression pattern
PBB GE OSBP2 221237 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23762 74309
Ensembl ENSG00000184792 ENSMUSG00000020435
UniProt Q969R2 Q5QNQ6
RefSeq (mRNA) NM_001003812 NM_152818
RefSeq (protein) NP_001269667 NP_690031
Location (UCSC) Chr 22:
31.09 – 31.3 Mb
Chr 11:
3.7 – 3.86 Mb
PubMed search [1] [2]

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.[1][2][3][4]

Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.[4]


  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  2. ^ Moreira EF, Jaworski C, Li A, Rodriguez IR (May 2001). "Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina". J Biol Chem 276 (21): 18570–8. doi:10.1074/jbc.M011259200. PMID 11278871. 
  3. ^ Wang C, JeBailey L, Ridgway ND (Jan 2002). "Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments". Biochem J 361 (Pt 3): 461–72. doi:10.1042/0264-6021:3610461. PMC 1222328. PMID 11802775. 
  4. ^ a b "Entrez Gene: OSBP2 oxysterol binding protein 2". 

Further reading[edit]