Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.
^Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature402 (6761): 489–95. doi:10.1038/990031. PMID10591208.
^Moreira EF, Jaworski C, Li A, Rodriguez IR (May 2001). "Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina". J Biol Chem276 (21): 18570–8. doi:10.1074/jbc.M011259200. PMID11278871.
Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res.8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID11258795.
Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res.42 (8): 1203–13. PMID11483621.
Henriques Silva N, Vasconcellos Fournier M, Pimenta G, et al. (2004). "HLM/OSBP2 is expressed in chronic myeloid leukemia". Int. J. Mol. Med.12 (4): 663–6. PMID12964051.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Wyles JP, Perry RJ, Ridgway ND (2007). "Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization". Exp. Cell Res.313 (7): 1426–37. doi:10.1016/j.yexcr.2007.01.018. PMID17350617.