OSCAR (gene)

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Osteoclast associated, immunoglobulin-like receptor
Symbols OSCAR ; PIGR3; PIgR-3
External IDs OMIM606862 MGI2179720 HomoloGene77042 GeneCards: OSCAR Gene
Species Human Mouse
Entrez 126014 232790
Ensembl ENSG00000170909 ENSMUSG00000054594
UniProt Q8IYS5 Q8VBT3
RefSeq (mRNA) NM_001282349 NM_001290377
RefSeq (protein) NP_001269278 NP_001277306
Location (UCSC) Chr 19:
54.6 – 54.61 Mb
Chr 7:
3.61 – 3.62 Mb
PubMed search [1] [2]

Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene.[1][2]

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[2]


Further reading[edit]

  • Pupello DF, Lipton M, Shumway NE (1976). "An unusual case of a bullet embolus.". The Journal of the Florida Medical Association 62 (11): 51. PMID 1185147. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Merck E, Gaillard C, Gorman DM et al. (2004). "OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells.". Blood 104 (5): 1386–95. doi:10.1182/blood-2004-03-0850. PMID 15155468. 
  • Merck E, de Saint-Vis B, Scuiller M et al. (2005). "Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses.". Blood 105 (9): 3623–32. doi:10.1182/blood-2004-07-2809. PMID 15650060. 
  • Tenca C, Merlo A, Merck E et al. (2005). "CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells.". J. Immunol. 174 (11): 6757–63. doi:10.4049/jimmunol.174.11.6757. PMID 15905516. 
  • Kim GS, Koh JM, Chang JS et al. (2005). "Association of the OSCAR promoter polymorphism with BMD in postmenopausal women.". J. Bone Miner. Res. 20 (8): 1342–8. doi:10.1359/JBMR.050320. PMID 16007331. 
  • Kim K, Kim JH, Lee J et al. (2005). "Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.". J. Biol. Chem. 280 (42): 35209–16. doi:10.1074/jbc.M505815200. PMID 16109714. 
  • Merck E, Gaillard C, Scuiller M et al. (2006). "Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils.". J. Immunol. 176 (5): 3149–56. doi:10.4049/jimmunol.176.5.3149. PMID 16493074.