Ocfentanil

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Ocfentanil
Ocfentanil.png
Systematic (IUPAC) name
N-(2-fluorophenyl)-2-methoxy-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide
Clinical data
Legal status
?
Identifiers
CAS number 101343-69-5 YesY
ATC code None
PubChem CID 60575
ChemSpider 54604 N
UNII MX52WBC8EV YesY
Synonyms Ocfentanyl, A-3217
Chemical data
Formula C22H27FN2O2 
Mol. mass 370.460 g/mol
 N (what is this?)  (verify)

Ocfentanil (INN) is an opioid analgesic that is an analogue of fentanyl and was developed in the early 1990s.[1] It is similar to fentanyl in effects, producing strong analgesia and sedation, but is slightly more potent, with 3μg/kg of ocfentanil being equivalent to 5μg/kg of fentanyl.[2]

Side effects of fentanyl analogues are similar to those of fentanyl, and include itching, nausea and potentially serious respiratory depression which can be life-threatening.

Synthesis[edit]

Ocfentanil synthesis: U.S. Patent 4,584,303

References[edit]

  1. ^ US Patent application 2002/176888 A1
  2. ^ Fletcher JE, Sebel PS, Murphy MR, Mick SA, Fein S. Comparison of ocfentanil and fentanyl as supplements to general anesthesia. Anesthesia and Analgesia. 1991 Nov;73(5):622-6. PMID 1952145