1-Octacosanol (also known as n-octacosanol, octacosyl alcohol, cluytyl alcohol, montanyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is common in the epicuticular waxes of plants, including the leaves of many species of , of most Eucalyptus forage and cereal grasses, of , Acacia , Trifolium and many other Pisum legume genera among many others, sometimes as the major wax constituent. Octacosanol also occurs in wheat germ. [1 ] [2 ]
Chemistry [ edit ]
Octacosanol is insoluble in water but freely soluble in low molecular-weight
alkanes and in chloroform.
Biological effects [ edit ]
Octacosanol is the main component in the mixture
policosanol. Octacosanol has been subject to preliminary study for its potential benefit for patients with [3 ] Parkinson's disease. [4 ] Studies have also found that octacosanol may inhibit the production of [5 ] cholesterol. [3 ]
References [ edit ]
^ EA Baker (1982) Chemistry and morphology of plant epicuticular waxes. pp139-165. In "The Plant Cuticle". edited by DF Cutler, KL Alvin and CE Price. Academic Press, London. ISBN 0-12-199920-3
^ "Octacosanol". Natural Products (Professional). drugs.com. Archived from the original on 3 June 2009 . Retrieved 9 July 2009. "isolated from wheat germ oil or other plants"
^ a b Taylor, Johanna C; Rapport, Lisa; Lockwood, G.Brian (2003). "Octacosanol in human health". Nutrition 19 (2): 192–5. doi: 10.1016/S0899-9007(02)00869-9. PMID 12591561.
^ Snider, SR (1984). "Octacosanol in parkinsonism". Annals of neurology 16 (6): 723. doi: 10.1002/ana.410160615. PMID 6395790.
^ Wang, T; Liu, YY; Wang, X; Yang, N; Zhu, HB; Zuo, PP (2010). "Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling". Acta pharmacologica Sinica 31 (7): 765–74. doi: 10.1038/aps.2010.69. PMID 20581854.