|Jmol-3D images||Image 1|
|Molar mass||130.23 g mol−1|
-16 °C, 257 K, 3 °F
195 °C, 468 K, 383 °F
|Solubility in water||Insoluble|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
The term Octanol usually refers to the isomer, octan-1-ol, with the molecular formula CH3(CH2)7OH. It is a fatty alcohol. Many other isomers are also known. Esters of octanol, such as octyl acetate, occur as components of essential oils. Octanol is manufactured for the synthesis of esters for use in perfumes and flavorings. It is used to evaluate the lipophilicity of pharmaceutical products.
- Al(C2H5)3 + 9 C2H4 → Al(C8H17)3
- Al(C8H17)3 + 3 O + 3 H2O → 3 HOC8H17 + Al(OH)3
The process generates a range of alcohols that are separated by distillation.
Octanol and water are immiscible. The distribution of a compound between water and octanol is used to calculate the partition coefficient 'P' of that molecule (often expressed as its logarithm to the base 10, log P). Water/ octanol partitioning is a relatively good approximation of the partitioning between the cytosol and lipid membranes of living systems.
Where a and b are constants, is the stratum corneum/ water partition coefficient, and is the water/ octanol partition coefficient. The values of a and b vary between papers, but Cleek & Bunge have reported the values a=0, b=0.74.
- Jürgen Falbe, Helmut Bahrmann, Wolfgang Lipps, Dieter Mayer "Alcohols, Aliphatic" in Ullmann's Encyclopedia of Chemical Technology Wiley-VCH Verlag; Weinheim, 2002. doi:10.1002/14356007.a01_279
- Schwarzenbach, Rene P.; Gschwend, Philip M.; Imboden, Dieter M. (2003). Environmental organic chemistry. John Wiley. ISBN 0-471-35053-2.
- McCarley KD, Bunge AL (2001). "Pharmacokinetic Models of Dermal Absorption". Journal of Pharmaceutical Sciences 90 (11): 1699–1719. doi:10.1002/jps.1120. PMID 11745728.
- Cleek RL, Bunge AL (1993). "A new method for estimating dermal absorption from chemical exposure. 1. General approach". Pharmaceutical Research 10 (4): 497–506. doi:10.1023/A:1018981515480. PMID 8483831.
- Bushara K. et al. (2004). "Pilot trial of 1-octanol in essential tremor". Neurology 62 (1): 122–124. PMID 14718713.