Octyl methoxycinnamate

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Octyl methoxycinnamate[1]
Octyl methoxycinnamate.svg
CAS number 5466-77-3 YesY
PubChem 5355130
ChemSpider 4511170 YesY
ATC code D02BA02
Jmol-3D images Image 1
Molecular formula C18H26O3
Molar mass 290.40 g mol−1
Density 1.01 g/cm3
Melting point −25 °C (−13 °F; 248 K)
Boiling point 198 to 200 °C (388 to 392 °F; 471 to 473 K)
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oil Health code 1: Exposure would cause irritation but only minor residual injury. E.g., turpentine Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Octyl methoxycinnamate (INCI) or octinoxate (USAN), trade names Eusolex 2292 and Uvinul MC80, is an organic compound that is an ingredient in some sunscreens and lip balms. It is an ester formed from methoxycinnamic acid and (RS)-2-ethylhexanol. It is a clear liquid that is insoluble in water.

Its primary use is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage. It is also used to reduce the appearance of scars.


Often used as an active ingredient in sunscreens combined with oxybenzone and titanium oxide.[2]

Safety studies[edit]

One study performed in 2000 raised safety concerns about octyl methoxycinnamate by demonstrating toxicity to mouse cells at concentrations lower than typical levels in sunscreens.[3][medical citation needed] However, a more recent study concluded that octyl methoxycinnamate and other sun screening agents do not penetrate the outer skin in sufficient concentration to cause any significant toxicity to the underlying human keratinocytes.[4] Estrogenic effects were noted in laboratory animals at concentrations close to those experienced by sunscreen users[5] and were also shown in test tube experiments.[6][unreliable source?]

See also[edit]


  1. ^ Merck Index, 11th Edition, 6687.
  2. ^ Serpone N, Salinaro A, Emeline AV, Horikoshi S, Hidaka H, Zhao JC. 2002. An in vitro systematic spectroscopic examination of the photostabilities of a random set of commercial sunscreen lotions and their chemical UVB/UVA active agents. Photochemical & Photobiological Sciences 1(12): 970-981.
  3. ^ Sinister side of sunscreens, Rob Edwards, New Scientist, 7 October 2000
  4. ^ Hayden, C. G. J.; Cross, S. E.; Anderson, C.; Saunders, N. A.; Roberts, M. S. (2005). "Sunscreen Penetration of Human Skin and Related Keratinocyte Toxicity after Topical Application". Skin Pharmacology and Physiology 18 (4): 170–174. doi:10.1159/000085861. PMID 15908756. 
  5. ^ http://www.food.dtu.dk/Admin/Public/DWSDownload.aspx?File=%2fFiles%2fFiler%2fPublikationer%2fPhDafhandlinger%2fph.d.-afhandling_Marta_Axelstad.pdf[dead link]
  6. ^ http://www.greenyour.com/body/personal-care/sun-care[dead link]