(E)-3-(4-methoxyphenyl) prop-2-enoic acid 2-ethylhexyl ester
|Molar mass||290.40 g·mol−1|
|Melting point||−25 °C (−13 °F; 248 K)|
|Boiling point||198 to 200 °C (388 to 392 °F; 471 to 473 K)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is: / ?)(|
Octyl methoxycinnamate (INCI) or octinoxate (USAN), trade names Eusolex 2292 and Uvinul MC80, is an organic compound that is an ingredient in some sunscreens and lip balms. It is an ester formed from methoxycinnamic acid and (RS)-2-ethylhexanol. It is a clear liquid that is insoluble in water.
||This section needs more medical references for verification or relies too heavily on primary sources. (April 2013)|
One study performed in 2000 raised safety concerns about octyl methoxycinnamate by demonstrating toxicity to mouse cells at concentrations lower than typical levels in sunscreens.[medical citation needed] However, a more recent study concluded that octyl methoxycinnamate and other sun screening agents do not penetrate the outer skin in sufficient concentration to cause any significant toxicity to the underlying human keratinocytes. Estrogenic effects were noted in laboratory animals at concentrations close to those experienced by sunscreen users and were also shown in test tube experiments.[unreliable source?]
- Amiloxate, a chemically related sunscreening agent
- Cinoxate, another cinnamic acid based sunscreen ingredient
- Sunscreen controversy
- Merck Index, 11th Edition, 6687.
- Serpone N, Salinaro A, Emeline AV, Horikoshi S, Hidaka H, Zhao JC. 2002. An in vitro systematic spectroscopic examination of the photostabilities of a random set of commercial sunscreen lotions and their chemical UVB/UVA active agents. Photochemical & Photobiological Sciences 1(12): 970-981.
- Sinister side of sunscreens, Rob Edwards, New Scientist, 7 October 2000
- Butt, S; Christensen, T (2000). "Toxicity and Phototoxicity of Chemical Sun Filters". Radiation Protection Dosimetry 91 (1-3): 283–286. Retrieved 7 June 2015.
- Hayden, C. G. J.; Cross, S. E.; Anderson, C.; Saunders, N. A.; Roberts, M. S. (2005). "Sunscreen Penetration of Human Skin and Related Keratinocyte Toxicity after Topical Application". Skin Pharmacology and Physiology 18 (4): 170–174. doi:10.1159/000085861. PMID 15908756.
- http://www.food.dtu.dk/Admin/Public/DWSDownload.aspx?File=%2fFiles%2fFiler%2fPublikationer%2fPhDafhandlinger%2fph.d.-afhandling_Marta_Axelstad.pdf[dead link]
- http://www.greenyour.com/body/personal-care/sun-care[dead link]