|Classification and external resources|
Oculogyric crisis (OGC) is the name of a dystonic reaction to certain drugs or medical conditions characterized by a prolonged involuntary upward deviation of the eyes. The term "oculogyric" refers to rotating of eyeballs, but several other responses are associated with the crisis. Epilepsy can manifest as oculogyric seizures, also called versive seizures.
Drugs that can trigger an oculogyric crisis include neuroleptics (such as olanzapine), carbamazepine, chloroquine, cisplatin, haloperidol, diazoxide, levodopa, lithium, metoclopramide, domperidone, nifedipine, pemoline, phencyclidine ("PCP"), reserpine, and cetirizine, an antihistamine.
Other causes can include postencephalitic Parkinson's, Tourette's syndrome, multiple sclerosis, neurosyphilis, head trauma, bilateral thalamic infarction, lesions of the fourth ventricle, cystic glioma of the third ventricle, herpes encephalitis, kernicterus and juvenile Parkinson's.
Symptoms and signs
Initial symptoms include restlessness, agitation, malaise, or a fixed stare. Then comes the more characteristically described extreme and sustained upward deviation of the eyes. In addition, the eyes may converge, deviate upward and laterally, or deviate downward. The most frequently reported associated findings are backwards and lateral flexion of the neck, widely opened mouth, tongue protrusion, and ocular pain. However it may also be associated with intensely painful jaw spasm which may result in the breaking of a tooth. A wave of exhaustion may follow an episode. The abrupt termination of the psychiatric symptoms at the conclusion of the crisis is most striking.
Other features that are noted during attacks include mutism, palilalia, eye blinking, lacrimation, pupil dilation, drooling, respiratory dyskinesia, increased blood pressure and heart rate, facial flushing, headache, vertigo, anxiety, agitation, compulsive thinking, paranoia, depression, recurrent fixed ideas, depersonalization, violence, and obscene language.
It is often not realized that in addition to the acute presentation, OGC can develop as a recurrent syndrome, triggered by stress, and exposure to the above drugs.
Immediate treatment of drug induced OGC can be achieved with intravenous antimuscarinic benzatropine or procyclidine; which usually are effective within 5 minutes, although may take as long as 30 minutes for full effect. Further doses of procyclidine may be needed after 20 minutes. Any causative new medication should be discontinued. Also can be treated with 25 mg diphenhydramine.
- oculogyric at eMedicine Dictionary
- Epilepsy A to Z: A Concise Encyclopedia:Second Edition By Pierre Jallon, MD,Peter Kaplan, MB, FRCP,William Tatum, page 360
- Praharaj SK, Jana AK, Sarkar S, Sinha VK; Jana; Sarkar; Sinha (December 2009). "Olanzapine-induced tardive oculogyric crisis". J Clin Psychopharmacol 29 (6): 604–6. doi:10.1097/JCP.0b013e3181c00b08. PMID 19910730.