Odanacatib

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Odanacatib
Odanacatib Structural Formulae V.1.svg
Systematic (IUPAC) name
N-(1-cyanocyclopropyl)-4-fluoro-N2-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)biphenyl-4-yl]ethyl}-L-leucinamide
Clinical data
oral
Identifiers
603139-19-1 YesY
None
PubChem CID 10152654
ChemSpider 8328162 N
UNII N673F6W2VH YesY
ChEMBL CHEMBL481611 N
Synonyms (2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-{[(1S)-2,2,2-trifluoro-1-{4'-(methanesulfonyl)-[1,1'-biphenyl]-4-yl}ethyl]amino}pentanamide
Chemical data
Formula C25H27F4N3O3S
525.56 g/mol
 N (what is this?)  (verify)

Odanacatib (pINN; codenamed MK-0822) is an investigational treatment for osteoporosis and bone metastasis.[1] It is an inhibitor of cathepsin K,[2] an enzyme involved in bone resorption.

It is being developed by Merck & Co.. The phase III clinical trial for this compound was stopped early after a review showed it was highly effective and had a good safety profile. It is expected Merck will apply for approval by late-2014. Cowen and Co predicted it will bring a billion a year in sales by 2020.[3]

This drug was developed at Merck Frosst in Montreal.

References[edit]

  1. ^ Le Gall, C. L.; Bonnelye, E.; Clézardin, P. (2008). "Cathepsin K inhibitors as treatment of bone metastasis". Current Opinion in Supportive and Palliative Care 2 (3): 218–22. doi:10.1097/SPC.0b013e32830baea9. PMID 18685424.  edit
  2. ^ Gauthier JY, Chauret N, Cromlish W et al. (February 2008). "The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K". Bioorg. Med. Chem. Lett. 18 (3): 923–8. doi:10.1016/j.bmcl.2007.12.047. PMID 18226527. 
  3. ^ "Merck to seek approval of osteoporosis drug, cites safety risks". Reuters. 2014-05-06.