The Ohio and Mississippi Railway (earlier the Ohio and Mississippi Rail Road) was a railroad operating between Cincinnati, Ohio, and East St. Louis, Illinois, from 1857 to 1893.
General Ormsby M. Mitchel was a civil engineer on this project.
The railroad started in 1854 and paralleled the Cincinnati and Whitewater Canal. Its East St. Louis terminal near the Mississippi River was completed in 1857. It was a founding rail line of the Terminal Railroad Association of St. Louis.
On September 17, 1861, during the American Civil War a train carrying union troops fell through a sabotaged bridge at Huron, Indiana injuring or killing 100.
On October 6, 1866, the Adams Express Company car was robbed by the Reno Gang just east of Seymour, Indiana becoming the first train robbery in US history.
It merged in 1893 with the Baltimore and Ohio Southwestern Railway, and is now part of CSX Transportation's Indiana Subdivision.
- ^ Goss, Rev. Charles Frederick (1912). Cincinnati: The Queen City. Cincinnati: The S.J. Clarke Publishing Company. pp. 186–187.