Olfactory marker protein

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olfactory marker protein
Identifiers
Symbol OMP
Entrez 4975
HUGO 8136
OMIM 164340
RefSeq NM_006189
UniProt P47874
Other data
Locus Chr. 11 q14-q21
Olfactory marker protein
PDB 1jyt EBI.jpg
solution structure of olfactory marker protein from rat
Identifiers
Symbol Olfactory_mark
Pfam PF06554
InterPro IPR009103
SCOP 1jyt
SUPERFAMILY 1jyt

In molecular biology, olfactory marker protein is a protein involved in signal transduction. It is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a beta sandwich consisting of eight strands in two sheets with a jelly-roll topology.[1] Three highly conserved regions have been identified as possible protein-protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch.[2]

External links[edit]

References[edit]

  1. ^ Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL (June 2002). "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction". J. Mol. Biol. 319 (3): 823–37. doi:10.1016/S0022-2836(02)00282-6. PMID 12054873. 
  2. ^ Smith PC, Firestein S, Hunt JF (June 2002). "The crystal structure of the olfactory marker protein at 2.3 A resolution". J. Mol. Biol. 319 (3): 807–21. doi:10.1016/S0022-2836(02)00242-5. PMID 12054872. 

This article incorporates text from the public domain Pfam and InterPro IPR009103