OmpA-like transmembrane domain

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OmpA-like transmembrane domain
1qjp opm.png
Symbol OmpA_membrane
Pfam PF01389
Pfam clan CL0193
InterPro IPR000498
SCOP 1bxw
TCDB 1.B.6
OPM superfamily 26
OPM protein 1qjp

OmpA-like transmembrane domain is an evolutionarily conserved domain of bacterial outer membrane proteins. This domain consists of an eight-stranded beta barrel.[1] OmpA is the predominant cell surface antigen in enterobacteria found in about 100,000 copies per cell.[2] The expression of OmpA is tightly regulated by a variety of mechanisms. One mechanism by which OmpA expression is regulated in Vibrio species is by an antisense non-coding RNA called VrrA.[3]

See also[edit]


  1. ^ Pautsch A, Schulz GE (November 1998). "Structure of the outer membrane protein A transmembrane domain". Nat. Struct. Biol. 5 (11): 1013–7. doi:10.1038/2983. PMID 9808047. 
  2. ^ Smith SG, Mahon V, Lambert MA, Fagan RP (August 2007). "A molecular Swiss army knife: OmpA structure, function and expression". FEMS Microbiol. Lett. 273 (1): 1–11. doi:10.1111/j.1574-6968.2007.00778.x. PMID 17559395. 
  3. ^ Song T, Wai SN (July 2009). "A novel sRNA that modulates virulence and environmental fitness of Vibrio cholerae". RNA Biol 6 (3): 254–8. doi:10.4161/rna.6.3.8371. PMID 19411843.