Oncostatin M receptor

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Oncostatin M receptor
Identifiers
Symbols OSMR ; OSMRB; PLCA1
External IDs OMIM601743 MGI1330819 HomoloGene2972 GeneCards: OSMR Gene
Orthologs
Species Human Mouse
Entrez 9180 18414
Ensembl ENSG00000145623 ENSMUSG00000022146
UniProt Q99650 O70458
RefSeq (mRNA) NM_001168355 NM_011019
RefSeq (protein) NP_001161827 NP_035149
Location (UCSC) Chr 5:
38.85 – 38.95 Mb
Chr 15:
6.81 – 6.87 Mb
PubMed search [1] [2]

Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.[1][2]

OSMR is a member of the type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.[1]

Clinical significance[edit]

The oncostatin M receptor is associated with primary cutaneous amyloidosis.[3]

References[edit]

  1. ^ a b "Entrez Gene: oncostatin M receptor". 
  2. ^ Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. PMID 8999038. 
  3. ^ Arita K, South AP, Hans-Filho G, et al (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. doi:10.1016/j.ajhg.2007.09.002. PMC 2253984. PMID 18179886. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.