Onisaburo had studied Honda Chikaatsu's "Spirit Studies" (Honda Reigaku), he also learned to mediate spirit possession (chinkon kishin) from Honda's disciple Nagasawa Katsutate in Shizuoka. He met the founder of Omotokyo in 1898 and in 1899 they established the Kinmeikai, later called Kinmei Reigakkai. In 1900 Kisaburō married Nao's fifth daughter Sumi and adopted the name Deguchi Onisaburō. Oomoto teaches that the guardian spirit of Nao is Amaterasu, described as a male spirit in a female body, and Onisaburo's spirit is Susanowo, a female spirit in a male body.
In 1908 he and Deguchi Nao founded the Dai Nihon Shūseikai which in 1913 became Taihonkyō and in 1916 the Kōdō Ōmoto. In 1923, he learned Esperanto, an international planned language, and introduced it to the activities of Oomoto.
A believer in the Oomoto maxim that it was humanity's duty to move forward together, bringing about a new age of existence on Earth, Onisaburo went to great lengths to promote the syncretic faith preached by Nao Deguchi. He wrote the Reikai Monogatari (Tales of the Spirit World), an 81-volume work which covered his alleged travels into the spiritual planes of existence, as well as many other theologically permeated stories which expounded on numerous Oomoto spiritual ideals.
Throughout his life, Onisaburo was often quite flamboyant, taking delight in wearing richly textured costumes of his own design and posing as a wide variety of deities, mostly Buddhist or Shinto. He would also dress as a shaman, and often even took up the appearances of female divinities. His outlook on life tended to be eclectic, sometimes even to the point of being outrageous. At varying points of his lifetime, he claimed to be an incarnation of Miroku Butsu (Sanskrit: Maitreya Buddha), and often referred to himself as a remodeller of the world.
Like most Oomoto followers, Onisaburo believed that the original kami founders of Japan, were driven away by the kami of the imperial line. This placed him in opposition to the authorities at the time, though he had the ability to hide it. This again differentiated him from Nao Deguchi, who was more open and direct in her proclamations. Onisaburo was quite talented in quieting the government officials while at the same time subverting their efforts that he found distasteful or amoral.
Onisaburo's legacy is largely concerned with art, including a wealth of calligraphic and poetic works. He also dabbled in cinema, sculpture, and pottery, leaving behind thousands of items which are now considered by many enthusiasts to be of great value.
- 松本健一 『出口王仁三郎 屹立するカリスマ』 リブロポート、1986年12月。ISBN 4-8457-0244-4。 114-116
- Nancy K. Stalker, "Prophet Motive: Deguchi Onisaburo, Oomoto and the Rise of New Religion in Imperial Japan," University Of Hawaii, 2008, ISBN 0-8248-3226-4
- Emily Groszos Ooms, Women and Millenarian Protest in Meiji Japan: Deguchi Nao and Omotokyo, Cornell Univ East Asia Program, 1993, ISBN 978-0-939657-61-2
- The Great Onisaburo Deguchi, by Kyotaro Deguchi, translated by Charles Rowe, ISBN 4-900586-54-4
- Murakami Shigeyoshi. Japanese Religion in the Modern Century. Translated by H. Byron Earhart. Tokyo, 1980. Originally published as Kindai hyakunen no shukyo. ISBN 978-0-86008-260-6
- The Moon of Onisaburo Deguchi
- Oomoto's Co-Founder, Onisaburo Deguchi
- Reading "The Great Onisaburo Deguchi" by Ruth Reiser
- Poem of Onisaburo in Kyoto