Oocyte selection

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Oocyte selection is a procedure that is performed prior to in vitro fertilization, in order to use oocytes with maximal chances of resulting in pregnancy. In contrast, embryo selection takes place after fertilization.

Techniques[edit]

Chromosomal evaluation may be performed. Embryos from rescued in vitro-matured metaphase II (IVM-MII) oocytes show significantly higher fertilization rates and more blastomeres per embryo compared with those from arrested metaphase I (MI) oocytes (58.5% vs. 43.9% and 5.7 vs. 5.0, respectively).[1]

Also, morphological features of the oocyte that can be obtained by standard light or polarized light microscopy. However, there is no clear tendency in recent publications to a general increase in predictive value of morphological features.[2] Suggested techniques include zona pellucida imaging, which can detect differences in birefringence between eggs, which is a predictor of compaction, blastulation and pregnancy.[3]

References[edit]

  1. ^ Strassburger D, Goldstein A, Friedler S, et al. (June 2009). "The cytogenetic constitution of embryos derived from immature (metaphase I) oocytes obtained after ovarian hyperstimulation". Fertil. Steril. 94 (3): 971–978. doi:10.1016/j.fertnstert.2009.04.035. PMID 19505687. 
  2. ^ Rienzi, L.; Vajta, G.; Ubaldi, F. (2010). "Predictive value of oocyte morphology in human IVF: a systematic review of the literature". Human Reproduction Update 17 (1): 34–45. doi:10.1093/humupd/dmq029. PMC 3001337. PMID 20639518.  edit
  3. ^ Ebner T, Balaban B, Moser M, et al. (May 2009). "Automatic user-independent zona pellucida imaging at the oocyte stage allows for the prediction of preimplantation development". Fertil. Steril. 94 (3): 913–920. doi:10.1016/j.fertnstert.2009.03.106. PMID 19439291.