OpenPHACTS

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Open PHACTS
Formation 2011
Type Public–private partnership
Purpose Semantic interoperability for drug discovery through Open innovation
Membership 27 member organisations
Key people
Website

Open PHACTS (Open Pharmacological Concept Triple Store) is public–private partnership between academia, publishers, enterprises, pharmaceutical companies and other organisations working to enable better, cheaper and faster drug discovery.[1][2][3][4] It has been funded by the Innovative Medicines Initiative,[5] selected as part of three projects to "design methods for common standards and sharing of data for more efficient drug development and patient treatment in the future".[6][7]

Partnerships[edit]

A total of 27 partners are currently involved including:

Drug discovery[edit]

The Open Pharmacological Space created by the consortium is intended to support open innovation and in-house non-public drug discovery research[8] by removing bottlenecks in drug development.[9][10] Resources from the project are publicly available on GitHub.[11]

To reduce the barriers to drug discovery in industry, academia and for small businesses, the Open PHACTS consortium is building the Open PHACTS Discovery Platform. This platform is freely available, integrating pharmacological data from a variety of information resources and providing tools and services to question this integrated data to support pharmacological research.

References[edit]

  1. ^ Williams, A. J.; Harland, L.; Groth, P.; Pettifer, S.; Chichester, C.; Willighagen, E. L.; Evelo, C. T.; Blomberg, N.; Ecker, G.; Goble, C.; Mons, B. (2012). "Open PHACTS: Semantic interoperability for drug discovery". Drug Discovery Today 17 (21–22): 1188–1198. doi:10.1016/j.drudis.2012.05.016. PMID 22683805.  edit
  2. ^ Ecker, G. F.; Williams-Jones, B. (2012). "Open Innovation in Drug Discovery". Molecular Informatics 31 (8): 519. doi:10.1002/minf.201280004.  edit
  3. ^ Gray, Alasdair J.G.; Groth, Paul; Loizou, Antonis; Askjaer, Sune; Brenninkmeijer, Christian; Burger, Kees; Chichester, Christine; Evelo, Chris T.; Goble, Carole; Harland, Lee; Pettifer, Steve; Thompson, Mark; Waagmeester, Andra; Williams, Antony John (2014). "Applying linked data approaches to pharmacology: Architectural decisions and implementation". Semantic Web 5 (2): 101–113. doi:10.3233/SW-2012-0088 (inactive 2014-09-27).  edit
  4. ^ Ciccarese, P; Soiland-Reyes, S; Belhajjame, K; Gray, A. J.; Goble, C; Clark, T (2013). "PAV ontology: Provenance, authoring and versioning". Journal of Biomedical Semantics 4 (1): 37. doi:10.1186/2041-1480-4-37. PMID 24267948.  edit
  5. ^ "Open PHACTS at IMI - The Innovative Medicines Initiative". 
  6. ^ Watson, R. (2011). "Europe provides €172m for research into innovative medicines". BMJ 342: d1577. doi:10.1136/bmj.d1577. PMID 21393337.  edit
  7. ^ Goble, C.; Gray, A. J. G.; Harland, L.; Karapetyan, K.; Loizou, A.; Mikhailov, I.; Rankka, Y. N.; Senger, S.; Tkachenko, V.; Williams, A. J.; Willighagen, E. L. (2013). "Incorporating Commercial and Private Data into an Open Linked Data Platform for Drug Discovery". "The Semantic Web – ISWC 2013". Lecture Notes in Computer Science 8219. p. 65. doi:10.1007/978-3-642-41338-4_5. ISBN 978-3-642-41337-7.  edit
  8. ^ Müller, S.; Weigelt, J. (2010). "Open-access public-private partnerships to enable drug discovery--new approaches". IDrugs : the investigational drugs journal 13 (3): 175–180. PMID 20191434.  edit
  9. ^ Dalgleish, R.; Molero, E.; Kidd, R.; Jansen, M.; Past, D.; Robl, A.; Mons, B.; Diaz, C.; Mons, A.; Brookes, A. J. (2012). "Solving bottlenecks in data sharing in the life sciences". Human Mutation 33 (10): 1494–1496. doi:10.1002/humu.22123. PMID 22623360.  edit
  10. ^ Mons, B.; Van Haagen, H.; Chichester, C.; Hoen, P. B. 'T.; Den Dunnen, J. T.; Van Ommen, G.; Van Mulligen, E.; Singh, B.; Hooft, R.; Roos, M.; Hammond, J.; Kiesel, B.; Giardine, B.; Velterop, J.; Groth, P.; Schultes, E. (2011). "The value of data". Nature Genetics 43 (4): 281–283. doi:10.1038/ng0411-281. PMID 21445068.  edit
  11. ^ "Open PHACTS on GitHub". Retrieved 2012-07-10.