McDoom was born and educated in London, England and received her Masters from Edinburgh University. She is of Guyanese descent and her name derives from her family's place of origin in the Essequibo Islands-West Demerara region of Guyana, McDoom village. She describes her surname as "a colonial mess-up," ascribed when the British mistakenly anglicized her father's family name.
McDoom joined Reuters in September 2002. She spent one year in London before moving to Cairo in July 2003 to cover Egypt and Sudan. The agency had her establish the first Reuters bureau in Sudan since the news service vacated that country 15 years prior. The bureau now consists of two full-time journalists, two TV crews, and a stringer. She is based in Khartoum, but files reports from throughout the country.
- Reporting War: A Western female journalist amongst warlords, Luna Pictures, Retrieved on June 3, 2008
- My Daughter's Sudan Wedding, Guyana Chronicle, Retrieved on June 3, 2008
- Sudan's 'wedding of the year', BBC News, Retrieved on June 3, 2008
- Darfur:An investigation into a tragedy, Reporters Without Borders, Retrieved on June 3, 2008
- Opheera McDoom, Sudan surrounds, attacks volatile Darfur camp - witness, Reuters, 22 August 2007
- Opheera McDoom, Armed men attack police in Darfur refugee camp, Reuters, 20 August 2007
- Opheera McDoom, Former Darfur rebels say Khartoum arming militia, Reuters, 16 August 2007
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