Optochin
| Optochin | |
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(4β,8α,9R)-6'-Ethoxy-10,11-dihydrocinchonan-9-ol |
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Other names
Ethylhydrocupreine |
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| Identifiers | |
| CAS number | 522-60-1  |
| PubChem | 71542 |
| MeSH | Optochin |
| Properties | |
| Molecular formula | C21H28N2O2 |
| Molar mass | 340.46 g/mol |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Optochin (or ethylhydrocupreine) is a chemical used in cell culture techniques for the presumptive identification of Streptococcus pneumoniae, which is optochin-sensitive, from other alpha-hemolytic streptococci such as Streptococcus viridans which are resistant. A common mnemonic is "OVRPS" (Optochin - Viridans Resistant, Pneumoniae Sensitive). Or "VROPS" (Viridans Resistant [to] Optochin, Pneumoniae Sensitive)
The growth of Bacteria that are optochin sensitive will be inhibited around an optochin disc, while the growth of bacteria that are optochin resistant will not be affected. In vitro a solution of as little as 1: 10,000,000 may be inhibitory to the pneumococcus, and 1: 500,000 is bactericidal.[1]
Resistance [edit]
Strains of Viridans Streptococci have been found to be resistant to optochin in laboratory testing.[2]
References [edit]
- ^ http://chestofbooks.com/health/materia-medica-drugs/Pharmacology-Therapeutics-Prescription-Writing/Ethylhydrocupreine.html
- ^ Pikis A, Campos JM, Rodriguez WJ, Keith JM (2001), "Optochin resistance in Streptococcus pneumoniae: mechanism, significance, and clinical implications", Journal of Infectious Diseases 184 (5): 582–590, doi:10.1086/322803, PMID 11474432
