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The Orbital part of inferior frontal gyrus is the part of the inferior frontal gyrus named opercularis (literally "the part that covers") because it covers part of the insula. The pars opercularis together with the pars triangularis form the Broca's area, a neuroanatomic region important in speech-language production.
Syudo Yamasaki et al. (1 September 2010) found that a significant gray matter volume reduction of both the pars opercularis and triangularis was found bilaterally in the subjects with Aspergers/Autism compared with typical control subjects. The effect size seemed to be larger for pars opercularis (1.25) than for pars triangularis (.90). The reduced volume of right as well as total pars opercularis showed a significant association with the increased severity of social communication problems in the Aspergers/Autism group.