Org 12,962

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Org 12,962
Org12962 structure.png
Systematic (IUPAC) name
1-(5-trifluoromethyl-6-chloropyridin-2-yl)piperazine
Clinical data
Legal status
  • Uncontrolled
Identifiers
CAS number 210821-63-9 N
ATC code ?
PubChem CID 9796408
ChemSpider 7972174 YesY
ChEMBL CHEMBL506999 YesY
Chemical data
Formula C10H11ClF3N3 
Mol. mass 265.662 g/mol
 N (what is this?)  (verify)

Org 12,962 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.[1] It was developed as a potential anti-anxiety drug, but was discontinued from human trials after tests in a public speaking challenge showed that its anti-anxiety effects were accompanied by side effects such as dizziness and a "spacey" feeling, which were attributed to poor selectivity in vivo over the hallucinogenic 5-HT2A receptor.[2]


See also[edit]

References[edit]

  1. ^ Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ (September 1999). "Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells". British Journal of Pharmacology 128 (1): 13–20. doi:10.1038/sj.bjp.0702751. PMC 1571597. PMID 10498829. 
  2. ^ Monck NJ, Kennett GA (2008). "5-HT2C ligands: recent progress". Progress in Medicinal Chemistry 46: 281–390. doi:10.1016/S0079-6468(07)00006-9. PMID 18381128.