Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions. Organic molecules can often contain a higher level of complexity compared to purely inorganic compounds, so the synthesis of organic compounds has developed into one of the most important branches of organic chemistry. There are two main areas of research fields within the general area of organic synthesis: total synthesis and methodology.
Total synthesis 
A total synthesis is the complete chemical synthesis of complex organic molecules from simple, commercially available (petrochemical) or natural precursors. In a linear synthesis—often adequate for simple structures—several steps are performed one after another until the molecule is complete. The chemical compounds made in each step are usually deemed synthetic intermediates. For more complex molecules, a different approach may be preferable: convergent synthesis involves the individual preparation of several "pieces" (key intermediates), which are then combined to form the desired product.
Robert Burns Woodward, who received the 1965 Nobel Prize for Chemistry for several total syntheses (e.g., his 1954 synthesis of strychnine), is regarded as the father of modern organic synthesis. Some latter-day examples include Wender's, Holton's, Nicolaou's and Danishefsky's synthesis of Taxol.
Methodology and applications 
Each step of a synthesis involves a chemical reaction, and reagents and conditions for each of these reactions need to be designed to give a good yield and a pure product, with as little work as possible. A method may already exist in the literature for making one of the early synthetic intermediates, and this method will usually be used rather than "trying to reinvent the wheel". However most intermediates are compounds that have never been made before, and these will normally be made using general methods developed by methodology researchers. To be useful, these methods need to give high yields, and to be reliable for a broad range of substrates. For practical applications, additional hurdles include industrial standards of safety and purity. Methodology research usually involves three main stages: discovery, optimisation, and studies of scope and limitations. The discovery requires extensive knowledge of and experience with chemical reactivities of appropriate reagents. Optimisation is where one or two starting compounds are tested in the reaction under a wide variety of conditions of temperature, solvent, reaction time, etc., until the optimum conditions for product yield and purity are found. Finally, the researcher tries to extend the method to a broad range of different starting materials, to find the scope and limitations. Total synthesis (see above) are sometimes used to showcase the new methodology and demonstrate its value in a real-world application. Such applications involved major industries focused especially on polymers (and plastics) and on pharmaceuticals.
Stereoselective synthesis 
Most complex natural products are chiral, and the bioactivity of chiral molecules varies with the enantiomer. Traditional total syntheses targeted racemic mixtures, i.e., as an equal mixture of both possible enantiomers. The racemic mixture might then be separated via chiral resolution.
In the latter half of the twentieth century, chemists began to develop methods of stereoselective catalysis and kinetic resolution whereby reactions could be directed to produce only one enantiomer rather than a racemic mixture. Early examples include Sharpless epoxidation (K. Barry Sharpless) and stereoselective hydrogenation (William S. Knowles and Ryōji Noyori). For their achievement, these workers went on to share the Nobel Prize in Chemistry in 2001. Such reactions gave chemists a much wider choice of enantiomerically pure molecules to start from, where previously only natural starting materials could be used. Using techniques pioneered by Robert B. Woodward and new developments in synthetic methodology, chemists became more able to take simple molecules through to more complex molecules without unwanted racemisation, by understanding stereocontrol. This allowed the final target molecule to be synthesised as one pure enantiomer without any resolution being necessary. Such techniques are referred to as stereoselective synthesis.
Synthesis design 
Elias James Corey brought a more formal approach to synthesis design, based on retrosynthetic analysis, for which he won the Nobel Prize for Chemistry in 1990. In this approach, the research is planned backwards from the product, using standard rules. The steps are shown using retrosynthetic arrows (drawn as ⇒), which in effect means "is made from". Computer programs have been written for designing a synthesis based on sequences of generic "half-reactions".
See also 
- Electrosynthesis, a synthetic method which uses electricity to initiate a desired chemical reaction.
- Organic Syntheses, a publication which gives detailed peer-tested laboratory procedures.
- Methods in Organic Synthesis, a journal
- Nicolaou, K. C.; Sorensen, E. J. (1996). Classics in Total Synthesis. New York: VCH.
- Woodward, R. B.; Cava, M. P.; Ollis, W. D.; Hunger, A.; Daeniker, H. U.; Schenker, K. (1954). Journal of the American Chemical Society 76 (18): 4749–4751. doi:10.1021/ja01647a088.
- March, J.; Smith, D. (2001). Advanced Organic Chemistry, 5th ed. New York: Wiley.
- John S. Carey, David Laffan, Colin Thomson and Mike T. Williams "Analysis of the reactions used for the preparation of drug candidate molecules" Org. Biomol. Chem., 2006, 4, 2337-2347. doi:10.1039/B602413K
- Corey, E. J.; Cheng, X-M. (1995). The Logic of Chemical Synthesis. New York: Wiley.
- Todd, Matthew H. (2005). "Computer-aided Organic Synthesis". Chemical Society Reviews 34 (3): 247–266. doi:10.1039/b104620a. PMID 15726161. More than one of
|last=specified (help); More than one of
|Wikimedia Commons has media related to: Organic syntheses|
- The Organic Synthesis Archive
- Chemical synthesis database
- Natural product syntheses
- Chemical synthesis semantic wiki