At the Battle of Gaugamela he fought on the right flank for king Darius III, with 40,000 infantry and 7,000 cavalry under his command. He died there.
Ironically his son, Mithrenes, Satrap of Lydia, had joined king Alexander III after being defeated at Sardis in 334 BC. He then fought at the Battle of Gaugamela on the side of Alexander. After the battle he was made Satrap of Armenia by Alexander.