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|Region of origin||Japanese|
Osaki or Ōsaki may refer to:
- Ōsaki, Miyagi, Japan
- Ōsaki, Kagoshima, Japan
- Ōsaki, Tokyo, a neighborhood in Shinagawa, Tokyo, Japan
- Nana Osaki, a fictional character from manga Nana
- Makoto Osaki, developer and supervisor at Sega AM2, involved with the Shenmue, Out Run, and Virtua Fighter games, among others
- Ōsaki Station, a railway station in Shinagawa, Tokyo, Japan
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