Omar Miguez scored five times for his country on the way to a World Cup winners medal in 1950. He played all four games Uruguay played, scoring a hat-trick against Bolivia in an 8-0 win in the play-off for the final group. He struck the other two against Sweden in the last fifteen minutes of their in the final group, turning the tie around to win 3-2. These goals turned out to be decisive for the Uruguayans, as their subsequent sensational defeat of Brazil would have been useless, had it not been for the victory against Sweden. He also played in the other two final group games against Spain and Brazil.
He also played in the 1954 World Cup. He scored three times in the group stage, once in a 2-0 win over Czechoslovakia and twice in a 7-0 win over Scotland. He also played in the quarter-final, defeating England 4-2, but was injured for Uruguay's defeats in the semi-final (4-2 a.e.t. against Hungary) and the third-place play-off (3-1 against Austria). From 1950-1958 he played 39 times scoring 27 goals which makes him the top 5th goalscorer for his country, only needing 4 goals to break the record.