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CAS number 33650-66-7 YesY
PubChem 441890
Jmol-3D images Image 1
Molecular formula C45H74O17
Molar mass 887.06 g mol−1
Appearance White crystals[1]
Melting point 202–204 °C[1]
Solubility in water Low in water.[2] Soluble in ethanol.[1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Osladine is a naturally occurring, high-intensity sweetener isolated from the rhizome of Polypodium vulgare.[3] It is a saponin, sapogenin steroid glycoside, 500 times sweeter than sucrose.[4]

A related compound, polypodoside A, has been identified from the of Polypodium glycyrrhiza and is 600 times sweeter than a sucrose solution at 6%.[2]

See also[edit]


  1. ^ a b c C.-R. Yang & O. Tanaka: Advances in Plant Glycosides, Chemistry and Biology. in Proceedings of the International Symposium on Plant Glycosides, August 12-15, 1997, Kunming, China; Elsevier, 1999. ISBN 978-0-444-50180-6
  2. ^ a b AD Kinghorn & CM Compadre, Alernative Sweeteners: Third Edition, Revised and Expanded, Marcel Dekker, New York, 2001. ISBN 0-8247-0437-1
  3. ^ J Jizba, L Dolejs, V Herout & F Sorm, « The structure of osladin — The sweet principle of the rhizomes of Polypodium vulgare L. », dans Tetrahedron Lett., vol. 18, 1971, p. 1329-1332 doi:10.1016/S0040-4039(01)96701-2
  4. ^ Yamada, H. und Nishizawa, M. (1995): Synthesis and Structure Revision of Intensely Sweet Saponin Osladin. In: J Org Chem. 60(2); 386–397; doi:10.1021/jo00107a018