|Part of AH84|
|Length:||365 km (227 mi)|
|Existed:||2006 – present|
|Regions:||Mediterranean, Southeastern Anatolia|
|Provinces:||Adana, Osmaniye, Gaziantep, Kahramanmaraş, Şanlıurfa|
|Major cities:||Adana, Osmaniye, Gaziantep, Şanlıurfa|
Otoyol 52 (English: Motorway 52), abbreviated as O-52, aka Adana-Şanlıurfa Otoyolu (English: Adana-Şanlıurfa Motorway), is a toll motorway in the regions of Mediterranean and Southeastern Anatolia in Turkey, connecting the cities Adana and Şanlıurfa. The motorway is part of European route E90 and Asian Highway 84.
The O-52 starts from the eastern terminus of Adana Beltway O-50, runs eastward through Osmaniye, Gaziantep and terminates north of Şanlıurfa. The section between Nizip, Gaziantep and Yılmaz, Şanlıurfa is still under construction.
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