|Length:||365 km (227 mi)|
|Existed:||2006 – present|
|Regions:||Mediterranean, Southeastern Anatolia|
|Provinces:||Adana, Osmaniye, Gaziantep, Kahramanmaraş, Şanlıurfa|
|Major cities:||Adana, Osmaniye, Gaziantep, Şanlıurfa|
Otoyol 52 (English: Motorway 52), abbreviated as O-52, aka Adana-Şanlıurfa Otoyolu (English: Adana-Şanlıurfa Motorway), is a toll motorway in the regions of Mediterranean and Southeastern Anatolia in Turkey, connecting the cities Adana and Şanlıurfa. The motorway is part of European route E90 and Asian Highway 84.
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