OLHCC was founded in 1916 as a two year normal school by the Marianites of Holy Cross. Its original location was in the Bywater area of New Orleans. It became a 4 year institution in 1938. In 1947, a 40-acre (16 ha) parcel of land in Algiers was donated to the Marianites. The college completed a move across the river to this new site in 1960. Its area was later reduced by a sale. Men were first admitted in 1967.
OLHCC is on a 16-acre (65,000 m2) campus in a middle-class residential neighborhood of the Algiers area of New Orleans on the west bank of the Mississippi River. It is built primarily in the Southern Colonial style.