He started his career as a journalist for Agence Tunis Afrique Presse (TAP). From 1983 to 1987, he worked as press secretary in the Tunisian embassy of Washington, D.C., and from 1987 to 1990 as the head of the D.C. branch of the Agence Tunis Afrique Presse. From 1991 to 1994, he worked as head of the D.C. branch of the Agence Tunisienne de Communication Extérieure (ATCE) and additionally as a Tunisian diplomat to the United States from 1991 to 1995. From 1995 to 2009, he was the chair of the ATCE. In 2009 he was appointed as communications minister. As such, he blamed satellite TV for promoting the veil.
Romdhani was one of the best Tunisian communication specialists. The dictator of Tunisia Ben Ali fired Romdhani in December 2010, just before the great popular Tunisian protest which toppled Ben Ali and forced him to flee the country to Saudi Arabia.
In July 2012, Romdhani became a regular columnist with the Dubai-based Gulf News. In his op-ed pieces he discussed the "lessons of the Arab Spring". He also criticized the "cronyism" of the Ben Ali regime and other flawed policies which led to the popular uprising against the regime.
- BusinessNews official biography
- 'Oussama ROMDHANI: Nouveau ministre de la communication et des Relations avec la Chambre des Députés, Babnet, 10 October 2009 
- Library of Congress webcast
- Yaroslav Trofimov, Faith at War: A Journey on the Frontlines of Islam, from Baghdad to Timbuktu, Picador, 2006, p. 43 
- Tunis lessons of the Arab Spring and the way ahead, Gulf News, July 8, 2012
- The looming danger in Maghreb region, Gulf News, July 21, 2012
- Assessing the mood on the Arab street, Gulf News, August 4, 2012