In this song, Bow Wow is thought to be addressing his breakup with Ciara, his former girlfriend. This was confirmed by Bow Wow himself when he mentioned her name during a performance of the song on 106 & Park. This song is thought to be a song about their break-up, in which was rumored to be a result of Bow Wow's sexual relations with one of Ciara's friend's Ashley R. (a video girl who appeared in the show College Hill: Atlanta). This song's video hit number 1 on "106 and Park" in just 7 days but after it went down to number 8 and then fell off the countdown, unlike his previous video "Shortie Like Mine" which went to number 1 and stayed on the countdown for 43+ days shortly after. The song uses a sample of Rick James' "Hollywood".
"Outta My System" debuted at number 76 on the Billboard Hot 100 the week of March 10, 2007. Ten weeks later, it peaked at number 22 the week of May 26, 2007. It stayed on the chart for twenty weeks. The single was certified platinum by the RIAA with over 1,000,000 copies shipped in the United States alone.