In this song, Bow Wow is thought to be addressing his breakup with Ciara, his former girlfriend. This was confirmed by Bow Wow himself when he mentioned her name during a performance of the song on 106 & Park. This song is thought to be a song about their break-up, in which was rumored to be a result of Bow Wow's sexual relations with one of Ciara's friend's Ashley R. (a video girl who appeared in the show College Hill: Atlanta). This song's video hit number 1 on "106 and Park" in just 7 days but after it went down to number 8 and then fell off the countdown, unlike his previous video "Shortie Like Mine" which went to number 1 and stayed on the countdown for 43+ days shortly after. The song uses a sample of Rick James' "Hollywood".
"Outta My System" debuted at #76 on the Billboard Hot 100 in March 2007 and eventually peaked at #22. The single was certified platinum by The RIAA with over 1,000,000 copies shipped in the United States alone.